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… DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s … Am I ready? I don’t know. I don’t know. We’ll see. Let’s find out.  DAN: All right, so the first person that I wanted … me towards the secondary metabolism side of things was looking at genomes and seeing where the really hard things …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … things that we don’t recognize, because the only way to find things is by comparison. We’ll talk about that when we … products. And so we’ve got another slide here, and we’re looking at a hand drawing – drawn by Selman Waxman, who was …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural … say that. I mean, we just proposed something, and if people find it useful then we have a set of rules that we can stick … So the conservation depends on the genomic lineage you are looking at. So that’s why the term “central,” or “primary,” …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … term for the special, natural chemical compounds that you find in plants, fungi and bacteria, basically all living … now. Maybe you want to describe that.  ALISON: Okay. We’re looking at a schematic of different pathways in a microbial …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … I’ll put some more info in the show notes, which you can find, along with a transcript at naturalproducts.com . We … cut his hair because it was too long. Well, when we went looking for a photo of John, we found one from the 70s in …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural … it in the show notes. Which I’ll remind you, you can always find at naturalprodcast.com . You should know we’ve recorded … setup– and yours, too, Dan. DAN UDWARY: Yeah, you’re looking very professional. ALISON TAKEMURA: Thank you. You, …

… now I’m working on this the afternoon of the day I’m due to release it, which is not ideal for me keeping myself on … went to group meeting and came back and it was just so fun looking at this as someone who had a bit more of a chemistry … for the first time getting excited about this. And so you find these clusters. And one can think about when we talk …

… in natural products right. There’s many different avenues toward chemistry. But that’s kind of where I had you. How … products chemists and biologists, natural products folks, looking at the tropics because of this immense amount of … well, why don’t we try to go to Alaska and see what we can find there. And so this was in part because the first time I …

… DAN: All right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. … in enzymes to do some of the reactions that chemists find really challenging. So that balance is really fun. … you get a new organism or a genome, let's say, and you're looking at clusters, is there something that kind of …

… Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real … of marine natural products, getting into the ocean and looking for molecules from the very beginning of the field. … the organic chemistry of the ocean? And I was shocked to find that there was almost nothing. Now, this is back in the …

… 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but I’m hoping that from here I can get … I put that link in the show notes, which you can always find through the JGI website at  naturalprodcast.com . … .  And that got me back a little bit to redox enzymes and looking at gene regulation. And then from there, I went to …

… DAN UDWARY: Hey everyone. Welcome back to Natural Prodcast. This continues the series of interviews … crossover, where us genome miners get really jazzed about finding enzymes that do unusual or unprecedented chemistry. … every different reaction that you want to do. If you’re not looking to develop a commercial process, you can have the …