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… Foster and too many others to name at JGI for the last two years or so. SMC is now released and ready for the public to … in natural products. That was my first exposure, my junior year as an undergrad. And to me, looking at the chemistry of … you go to the website, which is smc.jgi.doe.gov , the stats page is showing me that right now we have just over a …

… on the backs of people who’ve done a lot of work over the years. We have a pretty good idea of what the different … is another community effort that’s been built up over the years and is really strong for finding lots of different … of Earth’s Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think …

… has a book called The Plant Hunter and I’ve read all 400 pages of her life and I feel like I have a new friend that … And so a path opened itself to me, just before my senior year of college, a chance to go to the Amazon and work with … wasn’t an MRSA strain at the time because that was in the 1980s. I’m showing my age now. So early 1980s we didn’t have– …

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… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, though, how …

… annotate, and bin viruses from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 … with long standing virus-host interactions. ISME J. 15, 1569–1584. https://doi.org/10.1038/s41396-020-00870-1 Roux, S. et al. (2019) Cryptic inoviruses …

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… because they’re so reactive. BEN: …going back to the 1950s. But the structure of which was not known until the … as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … drug conjugates, abbreviated as “ADC”, was approved in the year 2000, and utilize the enediyne as the payload. We call …

… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, you’re like, famous. Dan: Famous? … natural products. And was at the university for over 40 years. There were four of us as kids in the family. I was …

… N., Roux, S. et al. Coassembly and binning of a twenty-year metagenomic time-series from Lake Mendota. Sci Data 11 , 966 (2024). https://doi.org/10.1038/s41597-024-03826-8 … Acids Research , Volume 51, Issue D1, 6 January 2023, Pages D723–D732, https://doi.org/10.1093/nar/gkac976 Roux, …

… been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise to … professor at the University of Rhode Island for a couple of years before I left that to join a biotech startup. And … about that.  DAN: Yeah, you know it took several hundred years for us to even understand that it was maybe natural …

… natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … biology got more sophisticated around the 80s and the 90s. And so we started to be able to explore DNA sequencing … has evolved over, you know, probably – possibly billions of years. And so it is pretty used to the way that the assembly …