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… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … this field either. So they used antiSMASH and they report findings using antiSMASH. And it’s actually quite a …

… from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … While, in general, requests will be for sequencing and its analysis, … Scientific merit is the major criteria used in evaluating proposals; however, the …

… technology to help access complicated natural product gene clusters, and we’re all really excited about that, and … So the enediyne was introduced clinically. And then the major application has come from Pfizer’s introduction of one … inspires us to discover the fundamentals and then apply the findings and to translate our fundamental findings into …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … terminal lake about 30 minutes away from campus. And we’re finding some really, really interesting compounds, and we’re … it was amazing. And now you have– just to the exponential expression of all these genomes and what can happen with all …

… that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … hundred examples, they were able to put dates on when major changes in the genes and chemistry happen, which I … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… so that was great for a while, but it’s not everything. So, finding new sources is somewhat problematic. And there’s a … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … if we can improve technology, for assembly and cloning and expression, we should be able to actually make the chemical …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … FRANCISCO BARONA-GOMEZ: Exactly. There is a problem of finding a PhD student that wants to work on something that … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of … experimental samples, including organisms (e.g. microbes, fungi, plant), media in which they grow, as well as …

…   Gain access to omics technologies generating community data at zero cost —  submit a proposal.  … of University and Research; all specimens collected and fungi isolated are preserved in the Culture Collection of Fungi from Extreme Environment, the Italian National …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … I take care of a museum of dead plants. I’m really good at finding and killing plants, so if you haven’t figured that … at Emory is where I did my undergraduate and I was a double major in Biology and I got introduced to this field of …

… I didn’t really know what that meant.  I was a chemistry major after being an optical engineering major after which … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … chemistry.  Dan: Yeah. Well we need more people like you finding the molecules so then we can tie them back to the …

… ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … in the nearby hills, then you could determine that by finding runoff. So you would go to the streams where the … not so much because we actually don’t know what the vast majority of those do. There’s another data portal out there …