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… and part 2 is here ) so you understand what’s happened so far in the conversation between me and Alison. In the … So you would find some new source that you hadn’t explored before. Like, you know, maybe it’s a new culture of a … this is the central dogma of molecular biology. And so DNA makes RNA makes protein. Something that’s you know …  …

… Anomaly” first described by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism … In particular during an era of ‘homology creep’, function prediction as purely based on annotation may not be … host interactions through global metagenomics.” Nature 578(7795): 432-436 (2020). Seshadri R., Leahy S. C., Attwood …

… that jazz. But I was in the same Department as both Wilfred Van der Donk and Doug Mitchell. And so I got a lot of … project. I will fully admit that, but it's been fun, so far, trying to play with that a little bit. JACKIE: So I … molecules were oftentimes diastereomeric mixtures, that makes it really challenging to actually interpret the data. …

… good question. I think that’s something we sort of covered in the other primers. So people should go back and … but then there will be a couple of genes in there where the light bulb will go off, and you’ll understand, oh, those … from that really larger set of data. And then this, as far as I’m aware, is the largest set of MAGs to date. Here, …

… a great program. This is one of my favorite interviews so far – you’re going to hear how passionate and enthusiastic … that Dan just described to you. So the enediyne referred to two carbon with a double bond. And “di” means two and … right? That’s the flavor of monoterpenoids. The very light natural product that gives you this fresh scent of the …

… this conversation about why the ocean was basically unexplored until the 70s, and how diving was the catalyst of that. … UDWARY: So Alison, I’m really excited today. We have, by far, I think, one of the most decorated and legendary … is in an adjacent cell that is also your cell. But what makes chemotherapy work is not that the target is unique, …

… Jackie Winter, has been on a few episodes now, and I figured we were way overdue to give her a proper introduction … it was– I like interacting with new people and seeing that light bulb go on when all of a sudden like, you know, that … like 2.5, 10 PPMs and just the size of the particle and how far they can actually travel. And that’s now starting to get …

… ALISON TAKEMURA: Hey, Dan. DAN UDWARY: So we’re back in our far corners of the world. So, yeah. ALISON TAKEMURA: That’s … I want to understand how secondary metabolites evolve– who makes them, how do they spread, why do they spread in a … of NaPDoS , this computer program which uses phylogeny to predict compounds. And so I really had to dig into all the …

… the genetic makeup of microbial communities, shedding light on their roles in various environments and their … of isotopes from labeled nutrients into biomass. When paired with metagenomics, qSIP can decipher active microbial … the implementation of prokaryotic systematics across cultured microbes and recovered population genomes using Average …

… genome mining in cave microbiomes, and using engineered biosynthetic pathways and enzyme systems to do synthetic … later. JACKIE WINTER: It’s pretty amazing, though, how far we’ve come, though, too when you start talking about … existed for millions of years and relatively stable– no lights, constant temperature, constant humidity. And they …

… one that the Hawaiian bobtail squid is famous for is the light organ.  And the light organ houses Vibrio fischeri, … is about the size of your pinky nail has maybe 50 to a hundreds of these. And so Spencer and his group have done the … out how to show this data and to do it in a way that makes sense. And I always call this the needle in the …