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… biochemical diversity within secondary metabolites, expanding their potential applications in the bioeconomy … function of these biologically significant compounds. By expanding the repertoire of secondary metabolites and …

… women get selected each year as a cohort to experience this 12-months leadership program, of which the last month is in … 3. And I currently co-leading the science program for the 12-months for Homeward Bound 5 and was meant to be in … found, or finding stuff that’s similar to things that we already know, then we probably need to start looking at all …

… the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the proposal. Also, once awarded, users have 12 months before they need to activate their project. … end of an active proposal in order to continue access in 12-month increments.  At the JGI, a typical proposal is …

… are very stable interactions that have been evolving for 300 million years, that could be a reasonable number if you … through a very long period of time, because you are already on a stable niche that you want to colonize and … you can assume with high confidence that they belong to the universe of natural product biosynthesis. So by merging the …

… support through the JGI (with the exceptions of DE-FOA-0003453 and DE-FOA-0003615 , which are both eligible for BERSS). … of Illinois at Urbana-Champaign: Announced in July 2017, CABBI is a collaboration between Illinois’ Institute …

… genomes,  we use it to identify and classify bacteria and archaea as well as gain insights into the evolutionary … catalog of Earth’s microbiomes. Nat Biotechnol 39 , 499–509 (2021). https://doi.org/10.1038/s41587-020-0718-6 I-Min A … Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth’s biomes. Nat Microbiol 4 , 1895–1906 …

… new partner, who, if you’re listening carefully, you might already know about. More on that later. But, now, here’s the … underwater. But thankfully that worked out. And I spent 30, 40 years diving all over the world and bringing samples … the ocean. We didn’t know whether to study bacteria, fungi, archaea, the whole range of microbial life. So, we just …

… their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their associated …

… some resources you can use to get caught up, if you’re not already familiar with them. DAN: So, here we go. Natural … called Mylotag. Wyeth was later acquired by Pfizer in 2009. So, a simple mistake, but I’m happy to be able to … genome, the genome predicts they often can produce around 30 – more than 30 compounds. So, this was a complete …

… use those data. Dan Udwary: Yeah. Marnix Medema: And I was already planning to start a group in computational biology of … this seed phase where you really need to get the input already from a smaller group of experts who say, OK, I also … some people went as far as saying, OK, we’re going to take 300 strains from our labs and measure them on their mass …

… Programs and Operations teams to enable the JGI’s focus on expanding molecular capabilities and functional genomics, …

… and whether we can activate these, utilizing some of these already synthesized molecules. DAN: OK. These receptors are … thioesterases, we were actually able to find approximately 300 with NRPSs nearby. And of those once we did the predictions, about 140 unique cyclic peptides. And from that, about 130 of them …