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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … secondary metabolite peptides. And there are two ways that nature does this. The more well-known secondary metabolism … has access to, which can be really weird and different, and makes for lots of variety in chemistry. The other way – the …

UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … I want to understand how secondary metabolites evolve– who makes them, how do they spread, why do they spread in a … some information about it, at least, even if there’s not a paper coming out, because you don’t think it’s worth …

… contain chlorine. And we saw this and started publishing papers. And one thing led to another. And we started … is in an adjacent cell that is also your cell. But what makes chemotherapy work is not that the target is unique, … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… products field as it relates to structure elucidation and genome mining, and how we might start to better connect … understand the chemical diversity and chemical utility that nature has to offer us. I found this conversation really … Some of the older articles aren’t digitized. And so that makes them hard to access. The articles – the structures in …

… the Chemistry department at the University of Utah, so that makes him one of Jackie’s colleagues. Aaron is doing some … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that … advisor as well. And he’s actually the one in a paper from the– I think when I was like six or eight or …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … this is the central dogma of molecular biology. And so DNA makes RNA makes protein. Something that’s you know …  … when you’ve got them, you know, strung out on a piece of paper. So it looks very clear. But biology is not that …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … some animals from eating the bark or something that makes them ill when they do. And so the natural products are … how funny, you know, the human endeavor of understanding nature is: we want to categorize things into these arbitrary …

… you, you can get transcripts, and show notes with links to papers around the science we talked about, at natural … exposure to working with Streptomyces, learning more about genome mining, as well as isolation and a little bit of … molecules were oftentimes diastereomeric mixtures, that makes it really challenging to actually interpret the data. …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … if they’re not stored properly. And so I read lots of your papers when I was in graduate school.    NANCY: Forced to!   … goes.    ALISON: Is this the only class of organisms that makes this polyketide structure that we’re aware of?   …

Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … repository of all the BGCs that we can put together. What makes it a little bit different beyond that– and sorry, I’m … and you spearheaded the genome mining class. And we got a paper out of that , and you taught everybody how to look at …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … But um, yeah, so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. … synthase kind of system, like, maybe this bacteria just makes fatty acids in a weird way. Or maybe it’s a secondary …

Menaka Wilhelm, who is the host of JGI’s other podcast, Genome Insider . If you’re a Genome Insider listener, then … specifically for my audience. But, yeah. So, Tanja, what makes a research project a good fit for working with the … not just one data set that serves the PI, and PI writes one paper and that’s it, and then the data set is really not …