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… that’s obviously a big question, and how you can start defining that type of metabolism. DAN UDWARY: So does … that’s a big question mark– why is it that we have these microorganisms that have truly secondary metabolism. The … it is more related to what JGI does, which is sequence genomes. And we just published last year in the Nature …

… and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … take the 100, 200 most important protein domains that are defining for biosynthetic pathways and let’s split these … kinds of data. And actually also for that we need also new standards and new platforms. So we’ve been recently working …

… tools and infrastructure as well as ensure cohesive data standards, the JGI partners with a number of facilities.  … … data on scales ranging from single genes and individual genomes to metagenomes to systems-level modeling and … System Biology Knowledgebase … National Microbiome Data Collaborative …

… a DOE Office of Science User Facility located at Lawrence Berkeley National Laboratory. Being a User Facility means … the bark of the yew tree, is where it was originally discovered. And so that sounds great. There’s a natural source, … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let us know! …

… on the JGI-UC Merced internship program, a similar collaboration with AAMU was launched in 2024.  … The CalTeach Summer Research Institute (SRI) at UC Berkeley is a program designed to foster a profound … methodologies within the realm of education. … Through the Berkeley Lab K-12 program, the JGI collaborates with Biotech …

… that usually lead to surprises and really great discoveries! And Eric’s done an awesome job, in that respect. … a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can find links to transcripts, … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let us know! …

… yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and … having the same protocols– I think, still looking into standards– how do you say, standardization? DAN UDWARY: … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let us know. …

… (DOE) Joint Genome Institute (JGI) commit to Lawrence Berkeley National Lab’s (Berkeley Lab’s) core values , which guide the … role models for the community, demonstrating the highest standards of ethical conduct guided by the JGI and Berkeley …

… oftentimes much more efficiently than we can in the lab. And so that's how I got interested in natural product … natural products by starting out in synthesis and then discovering more-- [LAUGHS] I don't know, practical or … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

Pool of variant libraries; sample sequencing to determine coverage of variants depends on project Fungal Minimal Draft … and quality of finished product depend on genome. Selected genomes will be improved based on feasibility and scientific … mass spectrometry Metabolite annotation based on chemical standards or computational approaches. Relative abundance of …

And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that … lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I think … to communicate with each other. And one would envision that microorganisms have evolved multiple variations of these …

… and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the … using genomics and multi-omics by working with research labs and culture collections to produce hundreds of diverse algal genomes, which will be made accessible through the PhycoCosm …