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… have to see if I’m going to slip a day on releasing it into the feeds, but I’m trying, you guys. Schedules are … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … for the project. DAN: Do you see broader applications for understanding these systems? AARON PURI: Yeah. Are you …

… and bioenergy crop enhancement. The program aims to tap into the largely unexplored biochemical diversity within … We have developed Regulon Identification by in vitro-sequencing (RIViT-seq) to identify RNA polymerase-sigma … twofold. We are also utilizing DNA-Affinity Purification (DAP) sequencing to express hundreds of transcription factors …

… in synthetic chemistry as were you and then made their way into the field of natural products in some way, shape, or … [project] with JGI, how many flavin monooxygenases are you sequencing, sort of along that vein, of if you have one or … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: …

… thought I’d take an academic job then, but I ended up going into industry. Saw a job at Roche, and that was to work with … MOUNCEY: Taking a bit of risk and then actually really adapting from there to dial in conditions and things. I think … NIGEL MOUNCEY: Oh, sure. I think our legacy obviously is in sequencing.  DAN: Of course.  NIGEL MOUNCEY: Sequencing the …

… by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which … begin filling this gap. A primary goal is to get  insights into the coding potential of candidate phyla  to decipher …

… than it is now. Or a little more– yeah, put more rationale into drug discovery by knowing what these things actually do … I think. DAN UDWARY: Yeah, and that was a JGI Community Sequencing Project. You’re right, yeah. NADINE ZIEMERT: Yes. … actually can learn just by really digging into the data and understanding what’s going on there. And now, that’s all I …

BARONA-GOMEZ: I think that the very first thing that got us into this is that we should, in any case, use definitions … terms of the definitions, such that everybody could have a understanding of what we’re talking about. And while … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

Microbes drive critical ecosystem functions and affect global nutrient cycling, however they … the viral genomics group aims at improving our collective understanding of ecological and evolutionary parameters …

… – problems that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, … Secondary Metabolites Science Program, which I was hired into, and my job is to do cool research, and also to talk to … in a cell or a living creature that make it specialized or adapted to its environment. Chemical- chemistry-wise. So it’s …

Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … supports researchers exploring how to convert sequence into functional assessments. The team has a research & …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … episode with her in the near future where we can dive into that. And I’m also dying to talk in more detail about … in everninomicin and analogs of that, you’re really understanding one specific biosynthetic pathway. I guess how …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … producing molecules that are helpful to the plants. And so, understanding those broader environmental and ecological … worked is people who were trying to find gold would go out into the hills. And they knew from example that gold is a …