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… started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology to help … he has an accent, and, so, I don’t really have any trouble understanding him, but I know from the download stats that … for every episode we put out. I actually put a lot of time into preparing those transcripts, so I hope somebody’s going …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … detoxifying soils, interacting with other organisms, and adapting to environmental changes. The program lays the … exploring the genetic basis of how plants have naturally adapted to varied climate and soil conditions around the …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … it will be really good to maybe start with how did you get into this field? How did you get into natural products? …

… have to see if I’m going to slip a day on releasing it into the feeds, but I’m trying, you guys. Schedules are … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … for the project. DAN: Do you see broader applications for understanding these systems? AARON PURI: Yeah. Are you …

… thought I’d take an academic job then, but I ended up going into industry. Saw a job at Roche, and that was to work with … MOUNCEY: Taking a bit of risk and then actually really adapting from there to dial in conditions and things. I think … NIGEL MOUNCEY: Oh, sure. I think our legacy obviously is in sequencing.  DAN: Of course.  NIGEL MOUNCEY: Sequencing the …

… capture microbial and viral diversity, leading to a better understanding of microbial communities and ecosystem … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … gain insights into microbial interactions, evolution, and adaptation, ultimately informing strategies for environmental …

… focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great … by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of …

… in synthetic chemistry as were you and then made their way into the field of natural products in some way, shape, or … [project] with JGI, how many flavin monooxygenases are you sequencing, sort of along that vein, of if you have one or … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: …

… than it is now. Or a little more– yeah, put more rationale into drug discovery by knowing what these things actually do … I think. DAN UDWARY: Yeah, and that was a JGI Community Sequencing Project. You’re right, yeah. NADINE ZIEMERT: Yes. … actually can learn just by really digging into the data and understanding what’s going on there. And now, that’s all I …

… BARONA-GOMEZ: I think that the very first thing that got us into this is that we should, in any case, use definitions … terms of the definitions, such that everybody could have a understanding of what we’re talking about. And while … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… – problems that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, … Secondary Metabolites Science Program, which I was hired into, and my job is to do cool research, and also to talk to … in a cell or a living creature that make it specialized or adapted to its environment. Chemical- chemistry-wise. So it’s …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … producing molecules that are helpful to the plants. And so, understanding those broader environmental and ecological … worked is people who were trying to find gold would go out into the hills. And they knew from example that gold is a …