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The program has been a pioneering effort in functional genomics since 2012, with a focus on addressing critical … Program plays a central role in advancing functional genomics, focusing on developing genetic systems that can … ICE and DIVA to rapidly design combinatorial construct variations. These constructs are subsequently synthesized …

… experiment types, with main focus areas being genome variation, transcriptomics and epigenomics. Our work varies in scope from the development of … ‘proof-of principle’ research projects to demonstrate new genomic capabilities. Our group also performs ‘proof-of …

… to: Build curiosity and illustrate the value of comparative genomic analysis Expose students to peer review process, … with some of the latest developments in microbial genomics, metagenomics, and computational biology, and to empower them …

… and anti-pest compounds.  The program is working to expand genomic resources for key plant species, enhancing our … and identification of small and large structural variation — this variation drives major phenotypic … on Phytozome … Phytozome is the JGI's Plant Comparative Genomics portal. Families of related genes representing the …

… which highlights our skewed understanding of microbial metabolism towards a minority of cultivated bacteria, still … focused on the application of  function-driven single-cell genomics . Here, single cells are characterized and selected … through global metagenomics.” Nature 578(7795): 432-436 (2020). Seshadri R., Leahy S. C., Attwood G. T., Teh K. H., …

… also dying to talk in more detail about the JGI Secondary Metabolism Collaboratory , which is the big huge monster … mechanistic enzymology to natural product biosynthesis to genomics to directed evolution– but it’s just the– it really … On target identification and cancer biology: “Apoptolidin family glycomacrolides target leukemia through inhibition of …

… conference, which took place a few weeks ago, in January of 2020. So, you might hear us referencing a conference, and … every environment you can think about.   DAN: What kind of genomic resources are available these days for the natural … have on cluster sets that are sort of the same. You know, family clusters, like if you looked at the statins, you …

… products and the science and scientists of secondary metabolism. Hey everybody, this is Dan with episode 13 of … of this is based on a really great paper that came out in 2020 where this is all explained in detail, so if you’d like … I think the important thing to remember is that, thanks to genomics, we now know that it is very hard to find stuff …

JACLYN WINTER: So I actually– well, I mean, not having family in science, it was hard to see what are the different … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … as many as it did and how that became sort of a trend in genomics. So anyway, yeah, JGI has been working in secondary …

The Community Science Program (CSP) provides the scientific community at large with access … of disciplines. Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that … PIs who have never led a JGI project, and the Functional Genomics call is for projects that translate genomic …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential … resistance. Cell . 184(13):3376-3393 Almeida A, et al. (2020) A unified catalog of 204,938 reference genomes from … Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and host interactions through …

… in. All proposals must be written in English. … The CSP and FICUS calls are open to both domestic and … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release … are encouraged to contact the JGI concerning other genomic resource needs. … Scientific merit is the major …