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We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning … structure and biogeochemical cycles. Research Team    … A complete publication list available at Google Scholar. …

DAN: Welcome back to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting … usually, these days, you’re probably going to do a complete genome sequence before you know you do a whole lot …   DAN: Got it.    NANCY: And this is really to complete the genomes, and I’m really thankful for this. It sort of goes …

… interview with my co-host Alison Takemura, who’s moved on from JGI to do real journalism, and we wish her all the … for you, we sequenced thousands for you or thousands metagenomes. And I think also the quality that we provide. So … process. So it’s really important to submit everything most completely. And then, there’s different sections that …

… conversation with Aaron Puri. He is an Assistant Professor from the Chemistry department at the University of Utah, so … in love with the bacteria part of that. And so I decided to completely change gears and go and do a postdoc with a woman … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that …

… maybe it’s a new culture of a new bacteria that you pulled from the soil, maybe it’s, you know, we talked about … we can find more things. Turns out some of the early genomes that were sequenced for, say, Streptomyces – they … it’s very hard. And it’s still not something that we’ve completely been able to tackle. And so – ALISON: So I do …

… genomic information using minute quantities of DNA derived from individual environmental cells. The proof of principle … capillary), researchers sequenced and assembled the first complete genome of an uncultured symbiont. The single cell … identify, and characterize more than 200 microbial genomes that were mapped to nearly 30 major previously …

… automation, and further advancing sequence applications, single cell genomics, DNA synthesis, and metabolomics.   … …

Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, Canada. … database which is now shared with the whole community in a completely free and open manner. But it is also … advancement in sort of both areas. And I suspect that no single change will resolve the problem. But that stepwise …

… interactions with their environments and with each other, from defending against predators to aiding in symbiotic … factors and determine their binding sites across multiple genomes. Computational prediction of heterologous … signatures of horizontal gene transfer. … The SMC provides complete sequence and annotation data for secondary …

… over our interview with Dr Elizabeth (or Betsy) Parkinson from Purdue University. She’s in the Department of Chemistry … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … know, I’m here to find a job. I would like to do something completely new. And that is to begin to study the organic … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… we get to present our conversation with Marnix Medema , from Wageningen University in the Netherlands. Marnix is still pretty young, but he’s been dead center and a lot of … and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get …