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… product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber to be a … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … soil. But we also have, in collaboration with other people, lake sediments. We have microbiomes from different …

… was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … there’s hot spots of really potent antibiotics. There’s cold spots where the pathogens are taking over and …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program … evolution. It also utilizes advanced tools, including deep learning algorithms for gene annotation and protein …

… underwater. But thankfully that worked out. And I spent 30, 40 years diving all over the world and bringing samples … the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve …

… not. And so the question of do you need something that’s promiscuous for it to be useful? Not in a process chemistry … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … got a more thermally stable protein, less working in the cold room. You know? DAN UDWARY: That’s right. Yeah. JACKIE …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … all based on antiSMASH results. And so if you want to do deeper analysis on things, then you’re staying in the “BiG” … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… activity. So the chemistry and function really of those microbes that live there.  And in our work we’ve determined … gone to retrieve some bacteria that like it to be really cold. Can you tell us more about that.  MARCY: Sure. In … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …

… products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of experimental samples, including organisms (e.g. microbes, fungi, plant), media in which they grow, as well as different types of environments (e.g. soil, lake).  A wide range of metabolites are identified using …

… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

Antarctic Museum (MNA-CCFEE). … The JGI was created in 1997 to unite the expertise and resources in DNA sequencing, … Science Program, characterize organisms (plants and microbes) relevant to the DOE science mission areas of … are at the core of many environmental processes, and the genetic makeup of microbial species and communities forms …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … and take soil and discover a new important drug from the microbes in that soil, there are now international … with heat is going to yield a different composition than a cold alcohol maceration. DAN UDWARY: Sure.  ALISON TAKEMURA: …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … products field, or secondary metabolism, has been … not dominated by, but driven by drug discovery. We know that …