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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … a relatively small genome, about five and a half million base pairs. It was not linear, like Streptomyces , but … the group has, I guess… Maybe my philosophy has sort of changed over the years. And I think maybe over the last 10 …

… FY 2026 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal  Actual Total*   Actual % of Goal   Goal (hours)**   Actual Total   Actual % Goal   FY …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … like BiG-scape and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us … a challenge, and there is actually some cases where we’ve changed things in antiSMASH because, well, some things were …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … It also enables exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With advanced mass spectrometry techniques and …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and it turns out it’s pretty engineerable – you can change the protein to some extent, and end up with a … And you can find them everywhere. They’re at the base of the animal kingdom, in terms of evolution. Because …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … see things that maybe aren’t real, and so it’s thought that based on historical records and weather recordings of the … slash natural product. And, can you just use that interchangeably? DAN: Sure. I mean, maybe — First, we can say, if …

… Antarctic algae need their vitamins; zinc fuels some of their most important functions. Even in the chilly waters … inhabit their frigid environment, Mock pointed out that as climate change warms polar waters, changes in trace metal … sequencing and computational analysis that enable systems-based scientific approaches to these challenges.  DOE’s …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you … families of genes that it searches for and uses a rule-based system that classifies the things that it finds into …

… research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … to identify new divergent lineages and expand the Tree of Life. We then investigate the coding potential to find … Exploring the fascinating world of giant viruses, which challenge our understanding of viral …

… DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … were, what they were doing in these genomes and how they change over time. And yeah, I mean, that was let’s see, … they’ve got really high GC content, which means their base usage is skewed, and that can mess with some of the …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … drive innovations that could advance our understanding of Earth’s ecosystems. … pathways, enabling modeling of microbiomes based on functional traits. These advancements provide new …

… DAN: Welcome back for episode 9 of Natural Prodcast. This week, Alison and I talk to Roger … NPAtlas, a freely accessible natural products structure database, which is going to be just invaluable to the natural … more to be gained than just subject matter, by making that change. So I went to the University of British Columbia, in …