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… … DAN: Welcome back for episode 9 of Natural Prodcast. This week, Alison and I talk to Roger … NPAtlas, a freely accessible natural products structure database, which is going to be just invaluable to the natural … more to be gained than just subject matter, by making that change. So I went to the University of British Columbia, in …

… … DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … guy named Matt Bogyo in grad school synthesizing activity based probes which are basically molecules that will … the bacteria part of that. And so I decided to completely change gears and go and do a postdoc with a woman named Mary …

… … Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … like BiG-scape and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us … a challenge, and there is actually some cases where we’ve changed things in antiSMASH because, well, some things were …

FY 2025 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2025 … PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY 2024 DOE …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and it turns out it’s pretty engineerable – you can change the protein to some extent, and end up with a … And you can find them everywhere. They’re at the base of the animal kingdom, in terms of evolution. Because …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … a relatively small genome, about five and a half million base pairs. It was not linear, like Streptomyces , but … the group has, I guess… Maybe my philosophy has sort of changed over the years. And I think maybe over the last 10 …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … see things that maybe aren’t real, and so it’s thought that based on historical records and weather recordings of the … slash natural product. And, can you just use that interchangeably? DAN: Sure. I mean, maybe — First, we can say, if …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … families of genes that it searches for and uses a rule-based system that classifies the things that it finds into … relevant! I promise!), talk about how genome sequencing has changed genome mining over the years, and we talk about a …

… … DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … were, what they were doing in these genomes and how they change over time. And yeah, I mean, that was let’s see, … they’ve got really high GC content, which means their base usage is skewed, and that can mess with some of the …

… dust hotspots on the lake. So the lake is [INAUDIBLE] with climate change. I mean, right now– like last year, we had a great … InterProScan. And all of those have ended up in the SMC database. There’s a web front end for it, and it’s just a …

… while, but Natural Prodcast is back again for another round of episodes. If you stick around for the next few months, … program is really not appropriate anymore. And so we changed it to a science program. MENAKA WILHELM: How cool. … really they’re asked by us to just review these proposals based on what’s uploaded, right? Don’t read between the …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … How can you design a drug, right? You design drugs  based on certain knowledge, without which, you know… If you … the natural product could be there. So this has really changed the paradigm of how to discover natural products. …