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So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to … a 6% successful drug discovery rate.   And this is 100 times better, on average, in comparison to the drug …

I always use it as the first word in the title of my talk, 100% fair for you to make that association. DAN UDWARY: So I … library within that family as possible. There’s one more category of sequences that we worked with JGI on, and those … But then, imagine though– OK, my group– I brought in like a 10-pound thing of candy corn. I like put it in a candy dish …

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… the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s … to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the … C, and you’ve got a new molecule, right? And so if you have 1000 A’s and 1000 B’s and 1000 C’s, then if you’ve got a …

… had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … to market or a new plant right to market takes about 10 years. Costs are in the range of $100 to $120 million to … 30 to September 1st. The link is found all over JGI’s web pages.  DAN: And I will put it in the show notes along with …

… for BERSS. For DNA synthesis requests, the minimum is 100 kb, and for metabolomics, at least 22 samples are … utilize a core facility instead. Proposals may not exceed 10 Tbp sequencing, 500 kbp synthesis, and 200 polar/500 … seeks to reduce U.S. gasoline consumption by 20% within 10 years through increased efficiency and diversification of …

… so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … in the field, these glacial bacteria grow slow and it’s not 100% clear that we know what their biological activities … call this the needle in the Haystack. Because if we have 10,000 features which one do we look at because we are a …

… has a book called The Plant Hunter and I’ve read all 400 pages of her life and I feel like I have a new friend that … I also feel like Cassandra Quave has put herself on the page and made herself really knowable through her book. And … these studies are lacking that. And so there’s no way to be 100% sure that the chemistry that they’re even reporting on …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … Brad: Yeah, at that time, that was new, right? Like, my god 10% of the genome makes small molecules that have, you know, … of changed over the years. And I think maybe over the last 10 years, I’ve really become a fan of having postdocs, and …