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… research; the vast majority of projects fall into this category. Users are responsible for their own living, local …

… I always use it as the first word in the title of my talk, 100% fair for you to make that association. DAN UDWARY: So I … library within that family as possible. There’s one more category of sequences that we worked with JGI on, and those … But then, imagine though– OK, my group– I brought in like a 10-pound thing of candy corn. I like put it in a candy dish …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., … soil ecosystem. Microbiome 11, 237. https://doi.org/10.1186/s40168-023-01666-z Neri U., Wolf, Y., Roux S., … clades of bacteriophages. Cell 185, 21. https://doi.org/10.1016/j.cell.2022.08.023 Roux, S., Paul, B.G., Bagby, S.C. …

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… the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s … to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the … C, and you’ve got a new molecule, right? And so if you have 1000 A’s and 1000 B’s and 1000 C’s, then if you’ve got a …

… Resour Announc 0:e00891-25. https://doi.org/10.1128/mra.00891-25 . B. Christenson, I. Nouioui, C. Daum, … Microbiol Resour Announc 0:e00506-25. https://doi.org/10.1128/mra.00506-25 J. Cusack, I. Del Rio, S. Spring, N. … Microbiol Resour Announc. 0:e00578-25. https://doi.org/10.1128/mra.00578-25 R. Lotito-Yde, H. Phea, C. Sachdeva, C. …

… microbiomes. mSystems0:e01744-24. https://doi.org/10.1128/msystems.01744-24 Oliver, T., Varghese, N., Roux, S. … Lake Mendota. Sci Data 11 , 966 (2024). https://doi.org/10.1038/s41597-024-03826-8 Nayfach, S., Roux, S., Seshadri, … Acids Research , Volume 51, Issue D1, 6 January 2023, Pages D723–D732, https://doi.org/10.1093/nar/gkac976 Roux, …

… had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … to market or a new plant right to market takes about 10 years. Costs are in the range of $100 to $120 million to … 30 to September 1st. The link is found all over JGI’s web pages.  DAN: And I will put it in the show notes along with …

… for BERSS. For DNA synthesis requests, the minimum is 100 kb, and for metabolomics, at least 22 samples are … utilize a core facility instead. Proposals may not exceed 10 Tbp sequencing, 500 kbp synthesis, and 200 polar/500 … seeks to reduce U.S. gasoline consumption by 20% within 10 years through increased efficiency and diversification of …

… so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … in the field, these glacial bacteria grow slow and it’s not 100% clear that we know what their biological activities … call this the needle in the Haystack. Because if we have 10,000 features which one do we look at because we are a …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … Brad: Yeah, at that time, that was new, right? Like, my god 10% of the genome makes small molecules that have, you know, … of changed over the years. And I think maybe over the last 10 years, I’ve really become a fan of having postdocs, and …

… has a book called The Plant Hunter and I’ve read all 400 pages of her life and I feel like I have a new friend that … I also feel like Cassandra Quave has put herself on the page and made herself really knowable through her book. And … these studies are lacking that. And so there’s no way to be 100% sure that the chemistry that they’re even reporting on …