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… been working in the Department of Energy. I really wasn’t known to them and they weren’t known to me.  DAN: Sure.  … are incredibly interested in this and have made tremendous advances in understanding how to harness the power of second … Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary metabolites. …

… and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … it didn’t. However – and this was a proposal on synthetic biology of engineering gene expression in bacteria – … forces instead of to make two competing tools. If we had known about your tool, Dan, we would have contacted you as …

I got the chance to do genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As … the pieces that attached to the other pieces, and sort of building out the puzzle from there to find that vein of … searches, but antiSMASH took, basically, all of the known things that were out there and created some good rule …

… chemistry work, you really see that there have been huge advances in both. The cool thing about genomes is you can, well, if your assembly is good, you can … we had to try and figure out what was there. Like, was it a known metabolite? Was it something new? And we could only do …

… and using engineered biosynthetic pathways and enzyme systems to do synthetic analoging of some really complex … and over that when we move into new chemical ecologies, new ecosystems, we find new chemistry. It worked in the marine … And I worked as an undergraduate for a pretty well-known guy, infamous person, actually. His name is Tomas …

… and develops others providing complementary expertise to advance the science and serve as impact multipliers . The … Center (NERSC) and data infrastructure projects—the DOE Systems Biology Knowledgebase (KBase) and the National Microbiome …

… research and for improving feedstock crops: Center for Advanced Bioenergy and Bioproducts Innovation , led by … (iSEE) and the Carl R. Woese Institute for Genomic Biology (IGB), and it will include 17 partner institutions. … of genome data, assistance in interpreting and/or building on an existing data set, or the refining of new …

… almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we … always. But often proteobacteria. We find chemistry that’s known, or sometimes novel, but often known, and yet the … to that and what you guys do when you’re exploring your systems. Because I think the JGI has a little bit of a …

… applications.  The team has three subgroups: Synthetic Biology Lab : a user science group dedicated to user project … engineering — to make them more user accessible Synthetic Biology Informatics Group : a team that develops data … Lead … More Resources … Software Engineers in the Synthetic Biology Informatics Group develop, deploy, and maintain …

… consists of coordinated hands-on experiments across fungal biology teaching labs. The purpose of the program is to: … Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ … and potential applications. … The Department of Energy Systems Biology Knowledgebase (KBase) is involved in the …

… useful! DAN: Among many other things, Ben is maybe best known as an expert in enediynes – that’s a class of natural … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly … to have an index. You have to have the computer-searching systems. So one of the enabling technologies we wanted to do …