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Mining Metagenomes for Cas Proteins
… acids (aa) in size, half that of previously known class 2 CRISPR enzymes that are typically 950—1400 aa. They were initially identified by searching for Cas12d homologs across IMG/M’s assembled metagenomic data. It … of the US Department of Energy under contract no. DE-AC02-05CH11231. The work was supported in part by grants from the …
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JGI@25: Tracking & Subduing the Plague of California’s Oak Woodlands
… In honor of the JGI's 25th anniversary in 2022, we have revisited a number of … plant disease, according to Garbelotto. In one year alone, 500 people participated in SOD Blitz activity, and these … 1;313(5791):1261-6. doi: 10.1126/science.1128796 Science News of the Day: Stokstad E. Genetics. Genomes highlight …
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Improved Draft Genome Sequence of Microbacterium sp. Strain LKL04, a Bacterial Endophyte Associated with Switchgrass Plants
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Natural Prodcast Episode 19: Bill Fenical
… FENICAL: I had begun diving when I was a teenager, about 15. I grew up in Northern California. And we’d go down to … seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … discovered this and it got developed in somewhere around 2004, I guess, something like that, and now, 2021, it doesn’t …
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Secondary Metabolites Program
… Development of cell-free based expression platforms: Only 10-20% of BGCs are expressed under standard laboratory …
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Examples: Successful LOIs & Submissions
… CSP Large-Scale LOI #2 … FICUS Example #2 …
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Tanja Woyke Elected to American Academy of Microbiology
… Scientific Achievement , and was among the Lab’s 2015 Women @ the Lab honorees. Woyke’s research focuses on … the AAM Fellows in this cohort. Go here for the full AAM news release. Woyke is also one of the organizers for the …
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Data Ecosystem
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JGI Portals
… Notices Data Portal files will be inaccessible July 22–July 24 for computing upgrades . We regret any inconvenience. … metagenomes, and metatranscriptomes. It features over 15 million viral genomes and fragments, enriched with … Portal was replaced with the Data Portal and sunset in 2026. The Genome Portal was designed to provide unified …
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Silver age of GOLD introduces new features
… The JGI’s Genomes OnLine Database celebrates 25 years as a vital resource for data contextualization The Science Since its launch 25 years ago, the  Genomes OnLine Database has matured from … Science of the U.S. Department of Energy operated [DE-AC02-05CH11231]; National Energy Research Scientific Computing …
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New and Improved: Eucalyptus Reference is Now Accessible
… | Genetics , with significant advances compared to the 2014 Eucalyptus grandis reference genome that has been … genome assembly and annotation. Genome contiguity of the 2025 phased reference and 2014 diploid genome reference was … had a gene annotation completement level of 93.8%. The 2025 assembly has a gene annotation completement level of …
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Microbiome Data Science Team
… the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science 2017, Nature Microbiology 2018), discovery of new genes with … dark matter through global metagenomics. Nature . 622(7983):594-602. Camargo AP. et al. (2023) Identification of mobile …
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