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Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa … genomes are critical to serve as phylogenetic anchors for metagenomes studies.  While uncovering the metabolic potential …

… technology in order to enhance the quality of single-cell genomes and directly link functional information with … the first quantitative Stable Isotope Probing (SIP) Metagenomics pipeline that utilizes internal analytical …

… to focus on expanding molecular capabilities and functional genomics, scaling capacity through end-to-end automation, and further advancing sequence applications, single cell genomics, DNA synthesis, and metabolomics.   … Deputy …

… in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to …

… percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than … metabolites and unidentified features in spectra. 167/214 Metagenome Metatranscriptome Environmental transcript sequence … Assembly, annotation ( IMG/M ), mapping 273/273 Metagenome Cell Enrichments Obtained by physical separation of a …

… of bacteria and archaea in their natural environments using single cell approaches. This includes linking strain-level genetic … and archaeal lineages to improve phylogenetic analysis, metagenomic annotations, and function distribution. These are …

ANI is used to ascertain the species specificity of single cells and genomes extracted from metagenomes, and also as a metric for quality control within …

… constraints exerted by viruses. Research in the viral genomics group aims at improving our collective … mechanisms involved in virus:host interaction and host cell take-over by viruses, and attempts to evaluate … ecosystem-level impacts of viral infections. The Viral Genomics Group is hosted within the Environmental Genomics …

… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: … DAN: Yeah, I don’t think your lab is gonna tackle that single handedly, right? So, yeah, getting the community …

… predict or just understand better the language of microbial cell-cell communication. And he told us about his work in … bound to it and maybe there will be some a affinity tag or a fluorescent tag, and so you can use that as a … and they were able to synthesize the genes for every single one of those and put them in individual plasmids and …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based …

… streams. This will all become clearer as we get into the genomics. So– ALISON TAKEMURA: I’m just enjoying the ride … if an order is uncultured (blue; represented only by metagenome-assembled genomes or MAGs) or cultured (gray; … and archaeal genomes that were created – these are Metagenome Associated Genomes, or MAGs. So these are genomes …