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… to see if I’m going to slip a day on releasing it into the feeds, but I’m trying, you guys. Schedules are hard. But, … bound to it and maybe there will be some a affinity tag or a fluorescent tag, and so you can use that as a … the community so far. But being here and then being at the Marine Natural Products meeting in Ventura where I got to …

… of Oceanography in San Diego. Bill is a pioneer of marine natural products, getting into the ocean and looking … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc … we want to talk a little bit about. It’s sort of early stages. But I think that is emblematic of some of the …

… 3 here ), which you should be able to find earlier in the feed, the secondary metabolism field has been dominated for … of that conference, and there should be a few more in the feed, that I’m releasing along with this one, at the same … me if I had some food for them which of course, I couldn’t feed the whole school.    ALISON: Where was this?   NANCY: …

… working with him.  We talk about his father, the legendary marine natural products chemist, Richard Moore, and get into … marine natural product biosynthesis and at the beginning stages of connecting molecules and genes. And then genomics … got the podcast. If you have a question, or want to give us feedback, tweet us @JGI, or to me @danudwary. If you want to …

… wouldn’t it be cool to look at these– it was actually marine invertebrates there– but look at these things in the … exciting. And why chemistry is so far behind in that stage is it’s still really difficult to do natural products … got the podcast. If you have a question, or want to give us feedback, tweet us @JGI or to me @danudwary. That’s D-A-N …

… and so we were able to actually not dive to collect the marine tunicates, which was nice because it’s also cold. And … we grow it on agar plates. And on that agar plate we often feed it lots of nutrients and in the process of giving it … That is one of the really big frontiers for the next stage of natural product drug discovery I think. Or even …

… with large collections of new microbes and new activities, feeds into some of your other research interests, Mark, … system. [ Go here to learn more about Cameron Currie’s metagenomics research, enabled in part by JGI’s Community … have something to do with it. We saw hints of a rare advantage. So if you’re not the most popular pathogen, you can …

… grade list of goals in life: on that list are being a marine biologist and being a chemist, and it’s actually … in their environment and eating them. They’re filter feeders that have a really important role on the reef and … end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  …

… quality. Yeah, for sure. NADINE ZIEMERT: Yeah, Dan… it’s a marine actinomycete bacterium. So they look kind of like … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot of … got the podcast. If you have a question or want to give us feedback, tweet us at JGI or to me at Dan Udwary. That’s …

… product dioxin ubiquinone, which actually comes from a marine bacterium. And so, I was working on chemically … allow that to bind. Your receptor also typically has some tag so that you can then pull down the receptor with that …

… of the problem, and then how machine learning, because it feeds on so much data, right, to learn features of interest. … if an order is uncultured (blue; represented only by metagenome-assembled genomes or MAGs) or cultured (gray; … come from all kinds of disparate environments. There’s some marine. There’s some soil samples. There’s human gut …

… nature does this with such elegance And also to take advantage of the biological properties that these molecules have … account? Or do you and your lab focus mainly on what can we feed this and what can it actually turn over? ALISON … to test that hypothesis through site-directed mutagenesis, we would end up with dead enzymes. So often, when …