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… of Oceanography in San Diego. Bill is a pioneer of marine natural products, getting into the ocean and looking … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc … we want to talk a little bit about. It’s sort of early stages. But I think that is emblematic of some of the …

… wouldn’t it be cool to look at these– it was actually marine invertebrates there– but look at these things in the … exciting. And why chemistry is so far behind in that stage is it’s still really difficult to do natural products … structure information. You still need structure at this stage, and you still need to put that information into …

… bound to it and maybe there will be some a affinity tag or a fluorescent tag, and so you can use that as a readout of activity. And I … the community so far. But being here and then being at the Marine Natural Products meeting in Ventura where I got to …

… grade list of goals in life: on that list are being a marine biologist and being a chemist, and it’s actually … end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  … ended up doing was pursuing with Jacques Ravel, at TIGR, metagenome sequencing, which was very early days for that …

… quality. Yeah, for sure. NADINE ZIEMERT: Yeah, Dan… it’s a marine actinomycete bacterium. So they look kind of like … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot of … of secondary metabolite pathways as viewed through metagenome studies, and what more JGI and others can do to …

… product dioxin ubiquinone, which actually comes from a marine bacterium. And so, I was working on chemically … allow that to bind. Your receptor also typically has some tag so that you can then pull down the receptor with that …

… working with him.  We talk about his father, the legendary marine natural products chemist, Richard Moore, and get into … marine natural product biosynthesis and at the beginning stages of connecting molecules and genes. And then genomics … would spend time between our two laboratories doing metagenomics, some genomics. We were a little concerned …

… were lost in other forms of  Chloroflexota that adapted to marine environments hundreds of millions of years ago.  The … Terrestrial  Chloroflexota have certain traits that most marine  Chloroflexota lost when they returned to an ocean … that enable organisms to swim around. However, genome and metagenomic sequencing conducted by the U.S. Department of …

… a mixture of, for example, metatranscriptome sequencing, metagenomics, single cell genomics. We even do the flow … for you, we sequenced thousands for you or thousands metagenomes. And I think also the quality that we provide. So … areas that are less of a focus, I would say. For example, marine research is not so much of a focus within BER …

… feedstock crops or model plants. Projects targeting marine systems must clearly demonstrate relevance and …