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DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes …

… … DAN UDWARY: Hey, everyone! Welcome to the “Self Promotion Episode” of Natural Prodcast. A … Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… in the early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of natural … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … amenable to work with, or even strains. And I think then it lends more to microbiology. And the more we have, the more …

You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … to go in the next couple years. And hopefully, some of the insights that we glean from that will be broadly applicable …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … how funny, you know, the human endeavor of understanding nature is: we want to categorize things into these arbitrary …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … natural product – they also often surprise us by giving us insights, inspires us to discover the fundamentals and then … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… and Sciences. She’s an ethnobotanist and the herbarium curator there, with a broad range of experimental work on plants … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … it’s not that easy. There are still not that many plant genomes, certainly nowhere close to bacterial kinds of …

… 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but I’m hoping that from here I can get … off today with my interview with the Director of the Joint Genome Institute and head of the Secondary Metabolites … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … might help it. And so maybe my being a communicator lends me to collect little stories and then share them at …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… … DAN: All right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. … exposure to working with Streptomyces, learning more about genome mining, as well as isolation and a little bit of … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …