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… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … Catalog of Earth’s Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) The GEM catalog … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … Metabolites Collaboratory SMC Workshop Materials from the 2023 JGI Annual Meeting Using the SMC Website API Endpoints …

So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … fundamentals. What is beautiful for natural products is nature! Nature does this sort of – if you think of nature as … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… strain and there have been years and years and years about 35-ish years, I think, now, studying Vibrio fischeri and … so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … do when you’re exploring your systems. Because I think the JGI has a little bit of a different approach. We don’t …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … Non-model Bacteria Check out the agenda for the JGI’s 2021 Annual Genomics of Energy & Environment Meeting   …

Natural Products conference, which took place last January 2020 in San Diego. San Diego, of course, is the “home turf” … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … of those, you know, early-on reactions that we see. And so nature does that as well. But it does it with exquisite …

… you guys. I’m trying really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m really happy … people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. … DAN: Oh, I did not know that. That's cool. JACKIE: But nature can do this. BETSY PARKINSON: But nature can do it …

… state of things, and what we’re hoping to accomplish at JGI in this area. If this series of podcast episodes has … recommend David Hopwood’s book called  “Streptomyces in Nature and Medicine.” It’s obviously focused more on the … the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s …

… secondary metabolite peptides. And there are two ways that nature does this. The more well-known secondary metabolism … can use peptides for! That’s what his collaboration with JGI is all about, and we talk about it a bit here. I have … But, say, the last time I checked, it was on the order of 10,000 species. And whenever you’re talking about a new …

… things I want to make sure that we talk about. You have a JGI project going with us that we want to talk a little bit … hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I …

… with my co-host Alison Takemura, who’s moved on from JGI to do real journalism, and we wish her all the best. … proposals as well. I’ve been at the JGI for 20 years, and 10 of those years, I’ve been a project manager. MENAKA … amount that they can request. So the minimum request is 100 kb. The maximum request is 500 kb. DAN UDWARY: For DNA …

… at over 270 places now worldwide with a rate of around 10,000 students a year. And that was those numbers were … that’s really popped up at funding agencies and the popular news recently because a lot of soldiers in the Iraq and … we have no idea what natural products are doing in nature. And it’s a really difficult thing to unpack …