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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … features of the compound. For example, lipids– doesn’t matter if it has one extra carbon or two or one less, at the … move a little bit away from that to try to unmask chemical dark matter. And the idea behind this is that, if we …

… know nothing about biology. Biology hates us. It’s a little dark, but. [laughs] DAN UDWARY: Yep. ALISON TAKEMURA: It’s … of the IMG data portal , which is a larger portal for microbial genomics. IMG stands for Integrated Microbial … can be applied to secondary metabolism almost always, no matter what that is. Almost always. How do people do that? I …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis … to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated … The Microbial Program focuses on using advanced sequencing …

… of thought with that. So some people are interested in cave microbial– people are interested in the more extreme … just now switching from intermicrobial interactions, studying intermicrobial interactions by imaging interactions … pharmacological properties. So they’re new compositions of matter. So one of the problems with the erythromycins and …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their … genetic elements. Beyond exploring and characterizing microbial diversity, work in the Metagenome Program uses … to assess microbial activity across ecosystems.  By studying microbial communities and their interactions, the …

… DAN: You’re listening to the US. .Department of Energy Joint Genome … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And … that on that timescale of the earth that geography doesn’t matter as much. But, you know, there’s clearly some, you …

… and that there might be more to be gained than just subject matter, by making that change. So I went to the University … to try and create an open source database of all known microbial natural products. So if you think about natural products science as a field, we have arguably been studying microbial natural products in an ordered way for …

… of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer … kept looking for open jobs that said, we want a chemist to study the ocean. And I didn’t find a single job … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so … I’m definitely seeing why this is such an important area to study. Okay, what’s your third story?  DAN: The third story …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … And so we’ve been working on that. But why small molecules matter is because this pain drug, this peptide that’s used, … crack this case, then that would open up our field to other study. And so it was kind of an early example, to try to …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … So like, as an undergraduate, I was like, no, I’m going to study architecture. I like making things and designing … then the organisms all around us or the, you know, the bio matter that’s around us now? Brad: Yeah, I mean, petroleum …

… Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I should ask, you … I wouldn’t say I was one of these people that wants to study oceanography and was fascinated by the oceans, though … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is …