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… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program … in the DOE Bioenergy Research Centers. The  Plant Gene Atlas initiative develops gene expression catalogs across …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … JGI scientists are able to link metabolic activity with gene expression, providing deeper insights into functional … a web-based service returns a list of scored reaction and gene matches associated with metabolites and a list of …

… he’s been leading an effort to build The Natural Product Atlas , or NPAtlas, a freely accessible natural products … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … my perspective, JGI has a large database of biosynthetic gene clusters and biosynthetic gene cluster fragments, and …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … Island. And was working on a natural products/biosynthetic gene cluster database, and a tool for predicting natural … have you applied them? Dan Udwary: Well, at JGI we have the Atlas of Biosynthetic Clusters . And this is a very raw …

… single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified … We will eventually construct a bioenergy plant single-cell atlas comprising Sorghum, Switchgrass, and Brachypodium …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … mentoring. I enjoyed teaching and just helping the next generation of researchers in natural products and in other … Genomics, there was a subsection of that called ABC, the Atlas of Biosynthetic Clusters. And at the time, it was a …

… at   Humboldt Universität zu Berlin   has developed an atlas that maps gene expression patterns in the  Arabidopsis root, profiling … applicable for non-model species for which fewer ‘marker’ genes are known that are hallmarks of different cell types.” …

ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … want to explain that to someone who doesn’t know much about genetics or anything else, science wise maybe, what genome … clusters. So, in the ABC portal here at JGI, ABC being the Atlas of Biosynthetic Clusters , which is a subsection of …

… of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … I could see a certain time span within these biosynthetic gene clusters. There’s gene fusion going on, and then I … before yours, we had Roger Linnington on to talk about NP Atlas. And we got talking about what it would take to expand …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … And Alison has done a really nice job of providing that general scientific audience whereas now I’m sitting here … And I was really fascinated by that. And really more generally from undergrad the intersection of chemistry and …