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… solutions to current problems facing humanity. A major focus are biofuel feedstock species and plant-microbe … support a plant based bioeconomy where plants are a major source of chemical production and contribute to a … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … program investigates the biological mechanisms that enable fungi and algae to play a vital role in carbon cycling, … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … I can say.  DAN: Sure, sure.  NIGEL MOUNCEY: So we had two major natural products projects that we had in my group … explore the regulation of biosynthetic gene cluster expression in organisms. And that’s led by Hiroshi Otani …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … spread since we're just doing bioinformatic searches. The majority of them are actinos, but not all of them are. … So that's been a really exciting part of this journey, is finding these enzymes that are capable of making those …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … JGI scientists are able to link metabolic activity with gene expression, providing deeper insights into functional … Here, a controlled environment of plant, microbes, fungi, etc may be established and subject to repeatable, …

… great example of probing fungi for natural products and finding new things. And so, really happy to have you here. … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … to grad school in microbiology. And certainly, I mean, the majority of it was focused on bacteria. And this was at MIT. …

… It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … point. So– BRIAN BACHMANN: So that was why– that’s a major focus of the group. Now, the cave organisms are there … BACHMANN: Exactly, and you can solve your problems by just finding a different producer. I mean, Bill Metcalf at UIUC …

… such as fully annotated genome assemblies or differential gene expression results. For DNA synthesis projects, JGI ships … is free of charge for non-proprietary research; the vast majority of projects fall into this category. Users are … We love to work with single organisms and mixed cultures of fungi, algae, protists, bacteria, archaea, viruses, plants, …

… natural chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your … what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … was maybe natural products that would cause some, you know, major historical events and craziness in human history.  …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … for us that are positive. And so drug discovery has been a major driver for natural product biosynthesis. And probably … are lots of reasons for that. But some of its due to just finding the same things over and over again. Once you find …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in … by one of these small molecules, how would you go about finding what that small molecule is? AARON PURI: Yeah. So …