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… to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … and reconstruct metabolic properties encoded within those genomes. Our aim is to more fully capture microbial and …

… involves both experimental and computational exploration of uncultivated viral diversity, characterization of molecular … While an ever-increasing number of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these viruses …

… Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … catalog of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom … environments. Integrating metatranscriptomes and metagenomes can, for instance, deepens our understanding of …

… of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted … estimates show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening … in the strongly biased representation of sequenced genomes in the public domain, the bulk of which belong to …

… to generate high-quality genomic datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria … catalog : Beyond minimal draft and improved draft microbial genomes the program offers single-cell sequencing, … Expansion of sequence space:  The JGI generates reference genomes from diverse bacterial and archaeal lineages to …

… technology in order to enhance the quality of single-cell genomes and directly link functional information with … Metagenomics pipeline that utilizes internal analytical standards to accurately measure environmental microbiome … assay lets us move beyond cataloging the genes of microorganisms and start making quantitative measurements …

… profiling transcription factor binding sites across entire genomes. This technology has been further scaled to a … community. The pipeline utilizes internal analytical standards to accurately measure environmental microbiome … DNA amplification, and sequence analysis to recover the genomes of uncultivated microbes. We also apply labeling …

… and quality of finished product depend on genome. Selected genomes will be improved based on feasibility and scientific … mass spectrometry Metabolite annotation based on chemical standards or computational approaches. Relative abundance of … mass spectrometry Metabolite annotation based on chemical standards or computational approaches. Relative abundance of …

… and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … take the 100, 200 most important protein domains that are defining for biosynthetic pathways and let’s split these … kinds of data. And actually also for that we need also new standards and new platforms. So we’ve been recently working …

… I got the chance to do genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As … so many bacteria, because it is so easy to sequence their genomes comparatively to especially plants. So yeah, so from … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let us know. …

… that’s obviously a big question, and how you can start defining that type of metabolism. DAN UDWARY: So does … that’s a big question mark– why is it that we have these microorganisms that have truly secondary metabolism. The … it is more related to what JGI does, which is sequence genomes. And we just published last year in the Nature …