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The CSP Functional Genomics call is to enable users to perform state-of-the-art functional genomics research and to help them translate genomic …

By understanding how microbes contribute to ecosystem functions, the Program helps drive innovations that could … Metagenome Program combines large-scale, time-series metagenomic data with detailed characterization of model systems … of uncultivated microbial lineages. Charting viral ‘dark matter’:   Viruses are abundant in the biosphere and …

… by bacterial or fungal metabolism by microbes, will have a functional role. We started from that. Evolution doesn’t … that’s obviously a big question, and how you can start defining that type of metabolism. DAN UDWARY: So does … I think the important thing to remember is that, thanks to genomics, we now know that it is very hard to find stuff …

The program provides high-quality, large-scale genomic data to advance microbial research that drives … applications. By expanding our knowledge of microbial functions and interactions, the Microbial Program supports … improve phylogenetic analysis, metagenomic annotations, and function distribution. These are derived from isolates and …

… the Eloe-Fadrosh group focuses on using genome-resolved metagenomic approaches to identify and characterize genomic information from uncultivated microbes and viruses. … better understanding of microbial communities and ecosystem function.  The Environmental Genomics group also hosts the …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential … of host-virus interactions, the exploration of the functional dark matter as well as the development of novel methods to …

… for people, but also those molecules that mediate a well functioning ecosystem and environment and earth. So yeah, … streams. This will all become clearer as we get into the genomics. So– ALISON TAKEMURA: I’m just enjoying the ride … know nothing about biology. Biology hates us. It’s a little dark, but. [laughs] DAN UDWARY: Yep. ALISON TAKEMURA: It’s …

… and biogeochemistry. This research helps translate their genomic potential into practical applications, including … strains. This approach allows for the identification of key functional traits that have direct applications in bioenergy … Fungi, with million species, are essential for ecosystem functioning — particularly in their roles associated with …

In particular during an era of ‘homology creep’, function prediction as purely based on annotation may not be … focused on the application of  function-driven single-cell genomics . Here, single cells are characterized and selected … into the phylogeny and coding potential of microbial dark matter. Nature 499, 431-7 (2013). Hess M., Sczyrba A., …

… of small molecules in biological systems, linking them with genomic data to enhance our understanding of genome science, … with genomic data to gain insights into how small molecules function within plants, microbes, and ecosystems. … designed to demystify the complexity of dissolved organic matter (DOM) across a variety of environments. ENVnet allows …

… program, the Joint Genome Institute provides advanced genomic capabilities, large-scale data and professional … critical minerals and materials. Understand the assembly, function, and the behavior of microbiomes and manipulate … constitute the largest reservoir of biodiversity and functional versatility on Earth. Their activities and …

And so we’ve been working on that. But why small molecules matter is because this pain drug, this peptide that’s used, … evidence was very indirect at that time. And why does that matter? It matters because there are a lot of potential drugs from …