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Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of … in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated … into the phylogeny and coding potential of microbial dark matter. Nature 499, 431-7 (2013). Hess M., Sczyrba A., …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, … of bacteria and archaea in their natural environments using single cell approaches. This includes linking strain-level genetic …

… genomic data and serving them to users via the Integrated Microbial Genomes & Microbiomes (IMG/M) system. Research … ANI is used to ascertain the species specificity of single cells and genomes extracted from metagenomes, and also as a …

… genetic elements. Beyond exploring and characterizing microbial diversity, work in the Metagenome Program uses … such as quantitative stable isotope probing (qSIP)-metagenomics and metatranscriptomics, to metagenomics and … of uncultivated microbial lineages. Charting viral ‘dark matter’:   Viruses are abundant in the biosphere and …

Applications group explores the genetic makeup of natural microbial communities using a variety of cutting-edge … technology in order to enhance the quality of single-cell genomes and directly link functional information with …

… host-virus interactions, the exploration of the functional dark matter as well as the development of novel methods to … A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell . 184(13):3376-3393 Almeida A, et … Bowers RM, et al. (2017) Minimum information about a single amplified genome (MISAG) and a metagenome-assembled …

Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer of marine … we want a chemist to study the ocean. And I didn’t find a single job advertisement. But one day, I decided to really … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no …

… parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and … mechanisms involved in virus:host interaction and host cell take-over by viruses, and attempts to evaluate … and potential biogeochemical impacts of globally abundant ocean viruses.  Nature . 537:689-93. … Selected Publications …

… percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than … Assembly, annotation ( IMG/M ), mapping 273/273 Metagenome Cell Enrichments Obtained by physical separation of a biologically relevant unit from a microbial community, such as a microcolony, microbial …

… program for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will … of Energy Joint Genome Institute, builds upon thousands of microbial genomes that have been sequenced by the JGI though … with some of the latest developments in microbial genomics, metagenomics, and computational biology, and to …

… to focus on expanding molecular capabilities and functional genomics, scaling capacity through end-to-end automation, and further advancing sequence applications, single cell genomics, DNA synthesis, and metabolomics.   … Deputy …

… of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties … within those genomes. Our aim is to more fully capture microbial and viral diversity, leading to a better … communities and ecosystem function.  The Environmental Genomics group also hosts the Viral Genomics group . …