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RIViT-seq technology could speed up associating transcription factors with their target genes. The Science Regulons are a group of genes that can be turned on or off … demonstrated the efficacy and potential of regulon identification by in vitro transcription-sequencing …

… of secondary metabolite biosynthesis: We have developed Regulon Identification by in vitro-sequencing (RIViT-seq) to identify RNA polymerase-sigma factor targets, …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis … to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with …

… saw a potential mechanism for why there would be this streamlining? NADINE ZIEMERT: Yes, and just how one certain … I think. DAN UDWARY: Yeah, and that was a JGI Community Sequencing Project. You’re right, yeah. NADINE ZIEMERT: Yes. … existing technology. And a lot of that was around chemical identification technology, mass spec, NMR. And we talked a …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better understand the …

… of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… … Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … to my submission, they were saying that natural product identification– biosynthetic gene cluster identification was …

… to unlock their potential for bioenergy, environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … and engineered strains. This approach allows for the identification of key functional traits that have direct …

Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it going?  DAN: Good. How are you?  MARCY: Am fine. I live in a … certainly the goal. I think with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … they won't. They've been turned these clustered situated regulons, but that might not be quite as true as we once … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

Research in the Woyke laboratory focuses on the utility of … of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … in one package so that it opened up secondary metabolism identification to anyone who wanted to do it. And it’s been …