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The JGI has a strong interest in seeing that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … acknowledgment (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … terrestrial biogeochemical processes, development of high performance plants and microbes, and understanding … diverse biological and environmental samples using advanced liquid chromatography mass spectrometry (LC-MS) based …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … we’ll say methyl so we call them methylotrophs [ muh-thigh-luh-trophs ]. This is like, every square is a … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … least a certain level of similarity. So if similarity was higher than a certain kind of volume. And if you do that, … now let’s look into detail, let’s make phylogenies of the underlying genes, let’s make alignments of those gene …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … that are produced, and we don’t know what potentially other targets, if there are actually other targets. So Firn and … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … So I built a lab to do that. And then yes, we had several targets– mechanistic enzymology targets and biosynthetic …

… of Natural Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … and so the quality – the data quality – was reasonably high. And yeah, it gave it gave us enough enough pairs of …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … by environmental change, focusing on plant resilience — highlighting the vulnerabilities of monocultures and the … the ability to discover syntenic orthologs, generate publication quality graphics and explore pangenome views of …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … Binding Protein. And so most people think of this as the targets of penicillin, so very important in that … trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did not know that. That's …

… mining and the directions it might take in the future. I highly recommend it. I’ll link to it in the show notes. … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …