The User Support Analysis group provides computational analysis for new technology development and JGI user science projects. We perform analysis for diverse experiment types, with main focus areas being genome variation, transcriptomics and epigenomics. Our work varies in scope from the development of highly customized analysis workflows for new product types, to the development of automated analysis pipelines for standard sequencing products performed at scale.
Our group also performs ‘proof-of principle’ research projects to demonstrate new genomic capabilities. Recent projects include analysis of the epigenomic landscape of bacteria (collaboration with PacBio and New England Biolabs), large scale annotation of gene function in Bacteria (collaboration with Deutschbauer group at LBNL), and engineering novel strains of phosphate-hydrolyzing plant root-associated bacteria (Collaboration with JGI DNA synthesis group).
More about Matt
|Jie Guo, Systems Analyst||Anna Lipzen, Systems Analyst||Vasanth Singan, Systems Analyst|
Matt Blow Bio
Dr. Blow joined the JGI in 2009, and currently heads the User Support Analysis group. He received his Ph.D. from the Wellcome Trust Sanger Institute and Cambridge University University in 2005, where he studied RNA editing and cancer genetics. Dr. Blow carried out postdoctoral work at LBNL, where he worked on computational and experimental approaches to study genome regulation in human and other vertebrate genomes. He joined JGI in 2009 where he has worked as a project scientist and research scientist on projects to develop functional genomic technologies and to understand genome function in bacteria. Since 2016 he has been the lead of the User Support Analysis group, with a goal of providing analysis support for JGI user science projects. The group performs custom analysis and develops automated pipelines for analysis of resequencing, transcriptome, epigenome and other functional genomics datasets generated by JGI user science projects.
- BS in Biochemistry and Biological Chemistry, Nottingham University, UK
- PhD in Genomics, University of Cambridge, UK
- Postdoctoral training Wellcome Trust Sanger Institute, UK and Lawrence Berkeley National Lab
Awards and Service
- Wellcome Trust Prize studentship
- Editorial board member for Scientific Reports
- Blow et al 2010. ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet, 42(9):806-10
- ENCODE Project Consortium. 2012.An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature, 489:57-74
- Attanasio et al. 2013. Fine Tuning of Craniofacial Morphology by Distant-Acting In Vivo Enhancers. Science, 342(6157)
- Nord Et Al. 2013. Rapid and Pervasive Turnover of Mammalian Enhancer Landscape During Development. Cell, 155:1521-31
- Visel et al. 2013. A High-Resolution Enhancer Atlas of the Developing Telencephalon. Cell, 152(4):895-908
- Wetmore et al. 2015. Rapid quantification of mutant fitness in diverse bacteria by sequencing randomly bar-coded transposons. MBio, 6(3):e00306-15
- Blow et al 2016. The Epigenomic Landscape of Prokaryotes. PLoS Genet, 12(2):e1005854