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… Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural products and the science and … topic in, arguably, my area of expertise, which is genome mining. You’ll hear us talk about what it is, hear me make a … set of MAGs to date. Here, at JGI, we took more than 10,000 metagenomes, many of which were sequenced at JGI, and some …

… computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … applications. By recovering population genomes from metagenomes, we gain insights into microbial interactions, … Profile HMM search across all IMG metagenomes, capturing sequence diversity for proteins of …

… Cas14 proteins discovered from JGI’s IMG/M database and … Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated proteins that can target single-stranded … DNA (ssDNA). The discovery was made possible by mining the datasets in the Integrated Microbial Genomes and …

… in natural environments. Integrating metatranscriptomes and metagenomes can, for instance, deepens our understanding of … of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes and metatranscriptomes. …

… with important biotechnological applications (e.g., new CRISPR-Cas variants and new CRISPR-Cas types) (Nature … novel methods to enable large-scale comparative analysis, mining and visualization of big data. … LB, et al (2018) Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science 362(6416):839-842. Duerkop BA, …

… the Molecular Foundry work might be really useful in such a case, because you can start the work with JGI first and then … Korea, Cuba, Iran, and Syria is fully restricted, except in cases where an individual born in one of these countries has … regulatory requirements. The user is responsible for determining which regulations or permit requirements are …

… enables users to validate hypotheses generated from mining genomic data by designing and assembling physical DNA … Check out our organism-agnostic CRISPR gRNA design tool  …

… Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural products and the science and … in natural product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot …

… and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these … improved annotation and functional prediction for phage proteins user-friendly integrated pipelines (MVP) and … identify, filter, cluster, annotate, and bin viruses from metagenomes. mSystems 9:e00888-24. …

… Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the science and scientists of … and his group to work on sequencing, synthesis and genome mining technology to help access complicated natural product … how nature is making compounds, but we are also applying CRISPR technology, anything as genome editing, genome …

… be episode 11. This continues our little sprint on genome mining. In the last episode , Alison and I talked about the … Yeah. There’s so much to do there especially looking at metagenomes. So we’re actually eager soon to also work on … from colleagues at Wageningen University who developed a CRISPR-Cas system for that group of bacteria and that …

… everyone and welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this … early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of natural product … cryo-EM studies to find the binding site. And then we did CRISPR and directed evolution to evolve resistance in the …