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… of Oceanography in San Diego. Bill is a pioneer of marine natural products, getting into the ocean and looking … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve …

In the ocean’s North Pacific Subtropical Gyre, microbes tend to stay localized at different depths. But … depths and relying on different ways of living. The Impact Microbes help regulate the global carbon cycle — fixing, … carbon. Understanding the metabolisms that SAR324 and other microbes use could inform scientists’ understanding of …

… techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those …

… then got funded to work for two years at the Max Planck for marine microbiology in Bremen, Germany. And I wanted to work … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to … about if a sugar beet might get disease, but then it’s microbes might help it. And so maybe my being a communicator …

… wouldn’t it be cool to look at these– it was actually marine invertebrates there– but look at these things in the … was at that did just this. And I discovered it was called “marine natural products.” And that person was Professor … what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where …

… product dioxin ubiquinone, which actually comes from a marine bacterium. And so, I was working on chemically … fun that we've started that is a different subject is from microbes to medicine labs. So this is-- we've been working … chance to actually learn a little bit more about how these microbes are isolated, but also learn a little bit more …

… has to have a story. And it can be looking for drugs from marine organisms, in which case you get to go to exotic … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off … called everninomicin, which is an octasaccharide and contains orthoester linkages and a couple of aryl groups. …

… just not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at Scripps. So we’re looking at biosynthesis of marine fungal metabolites. We’re also looking– now we’re … of Utah , about her secondary metabolism research on novel microbes and bioactive compounds in the Great Salt Lake. …

… product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber to be a … quality. Yeah, for sure. NADINE ZIEMERT: Yeah, Dan… it’s a marine actinomycete bacterium. So they look kind of like … only grow in saltwater. So we’re thinking they’re obligate marine. There’s so far no species or no strains known that …

… grade list of goals in life: on that list are being a marine biologist and being a chemist, and it’s actually … of your research? I know you’ve generally worked in various marine organisms. Except during the time that we worked in … of the compounds that I thought was really cool – found in marine animals – was a peptide. And we had no idea how it …

Science Program, characterize organisms (plants and microbes) relevant to the DOE science mission areas of … needed to design, build, and control plants and microbes to produce biofuels, … of organics will not be considered. Projects targeting marine systems must clearly demonstrate relevance and …