“There are a lot of different tools used for predicting genes in prokaryotes,” Kyrpides said. “The major problem we have is that they all produce very variable results. This impedes our ability to compare genomes sequenced and annotated from various sources, as they use different tools for gene prediction. GenePRIMP is not substituting any of the available methods; a user can employ any available automatic gene prediction method, and then use GenePRIMP to correct the initial output. It will generate a much more standardized output, thus not only significantly improving quality, but also significantly facilitating comparative analysis.”
Read more (and watch the video) on PhysOrg.