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Do metabolic pathways from engineered yeasts still work in cell-free environments? … can push more of the carbon that we feed into a product molecule and so we’re able to make the same amount of a … grams per Liter-hour in a system optimized for developing small-scale prototypes. Additionally, the team also used a …

The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, … Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned … Synthesis Constructs 5-10kb in size Single gene or multiple small genes assembled totaling 5-10kb in length, cloned into …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to …

… bond. And then you know, the rest of a natural product molecule around that. That’s sort of a semi-stable … toxic molecules, and that human beings know, today, for small molecules. So they’re in the picomolar range. ALISON: … are the biological version of the catalyst to catalyze the production of the natural product. So that was my PhD study, …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First … analoging of some really complex bioactive natural product molecules. It’s a wide ranging conversation, and we could … that need to defend each other or subdue one another with small molecules. DAN UDWARY: Antibiotics, yeah, to fight …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … it just so happens that bacteria make a lot of the kinds of molecules that humans find useful as drugs. So yeah, so … any water that washed down off the hills might carry small pieces of gold along with them and end up in the beds …

… actually are able to make some of these really interesting molecules, oftentimes much more efficiently than we can in … when I started doing a lot of this natural product production within bacteria, they're great at it, but it … So cis versus trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did …

… bioeconomy where plants are a major source of chemical production and contribute to a healthier planet and a … agriculture, including the development of complex biomolecules — which can include antimicrobial and anti-pest … The pangenomes enable the exploration and identification of small and large structural variation — this variation drives …

… is Professor Cassandra Quave from Emory University, with joint appointments in the School of Medicine and College of … heard of anthropology. This is– I grew up in a very rural, small town. We didn’t have AP or IB courses or any of these … And so I think that there are really interesting small molecules in nature that are just waiting to be found. …

… of Natural Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, … Panama, straight out of my graduate school, and was given a small lab in the National Science Center there and ran this … was very much medicinal chemistry. My job was to make a molecule a day. And one of the things I wanted from that …

… of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an important one that … the normal amount that we get, which is already a fairly small number. We’re a very niche podcast. And so maybe if we … as an undergrad. And to me, looking at the chemistry of the molecules and then looking at how they were made was really …

… community itself works together to elicit new metabolite production. And we are also interested in how the jelly … Dan: Yeah. Well we need more people like you finding the molecules so then we can tie them back to the gene clusters … chemistry but I think that’s not necessarily – There are small molecules that host make as well. And so hosts and …