|A spoonful of soil contains a complex and diverse microbial community. Informatics capabilities are proving to be bottlenecks in metagenomicstudies. by Chiot’s Run|
In an article published in the February 2012 issue of Current Opinion in Biotechnology, DOE JGI’s Patrick Chain at Los Alamos National Laboratory and colleagues discuss the bottlenecks in current metagenomic studies. One example of an informatics obstacle is that the short-read sequencing algorithms currently used to assemble individual genomes from a community take up too much computer memory. Another problem is that the current annotation tools used for metagenomic studies are based on bacterial annotation tools and as such, don’t consider the viral or eukaryotic components of the sample.