Phytozome is the Plant Comparative Genomics portal of the Department of Energy’s Joint Genome Institute. Families of related genes representing the modern descendants of ancestral genes are constructed at key phylogenetic nodes. These families allow easy access to clade-specific orthology/paralogy relationships as well as insights into clade-specific novelties and expansions. As of release v11, Phytozome provides access to sixty-five sequenced and annotated green plant genomes, fifty-two of which have been clustered into gene families at 15 evolutionarily significant nodes. Each gene has been annotated with PFAM, KOG, KEGG, PANTHER and GO assignments, where possible. Query-based data access is provided by Phytozome’s PhytoMine and BioMart instances, while bulk data sets can be accessed via the JGI’s Genome Portal (registration required).JBrowse genome browsers are available for all genomes.