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    Data yielded from RIViT-seq increased the number of sigma factor-gene pairs confirmed in Streptomyces coelicolor from 209 to 399. Here, grey arrows denote previously known regulation and red arrows are regulation identified by RIViT-seq; orange nodes mark sigma factors while gray nodes mark other genes. (Otani, H., Mouncey, N.J. Nat Commun 13, 3502 (2022). https://doi.org/10.1038/s41467-022-31191-w)
    Streamlining Regulon Identification in Bacteria
    Regulons are a group of genes that can be turned on or off by the same regulatory protein. RIViT-seq technology could speed up associating transcription factors with their target genes.

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    (PXFuel)
    Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
    In a special issue of the journal Synthetic Biology, JGI scientific users share how they’ve worked with the JGI DNA Synthesis Science Program and what they’ve discovered through their collaborations.

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    A genetic element that generates targeted mutations, called diversity-generating retroelements (DGRs), are found in viruses, as well as bacteria and archaea. Most DGRs found in viruses appear to be in their tail fibers. These tail fibers – signified in the cartoon by the blue virus’ downward pointing ‘arms’— allow the virus to attach to one cell type (red), but not the other (purple). DGRs mutate these ‘arms,’ giving the virus opportunities to switch to different prey, like the purple cell. (Courtesy of Blair Paul)
    A Natural Mechanism Can Turbocharge Viral Evolution
    A team has discovered that diversity generating retroelements (DGRs) are not only widespread, but also surprisingly active. In viruses, DGRs appear to generate diversity quickly, allowing these viruses to target new microbial prey.

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    Photograph of a stream of diatoms beneath Arctic sea ice.
    Polar Phytoplankton Need Zinc to Cope with the Cold
    As part of a long-term collaboration with the JGI Algal Program, researchers studying function and activity of phytoplankton genes in polar waters have found that these algae rely on dissolved zinc to photosynthesize.

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    This data image shows the monthly average sea surface temperature for May 2015. Between 2013 and 2016, a large mass of unusually warm ocean water--nicknamed the blob--dominated the North Pacific, indicated here by red, pink, and yellow colors signifying temperatures as much as three degrees Celsius (five degrees Fahrenheit) higher than average. Data are from the NASA Multi-scale Ultra-high Resolution Sea Surface Temperature (MUR SST) Analysis product. (Courtesy NASA Physical Oceanography Distributed Active Archive Center)
    When “The Blob” Made It Hotter Under the Water
    Researchers tracked the impact of a large-scale heatwave event in the ocean known as “The Blob” as part of an approved proposal through the Community Science Program.

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    A plantation of poplar trees. (David Gilbert)
    Genome Insider podcast: THE Bioenergy Tree
    The US Department of Energy’s favorite tree is poplar. In this episode, hear from ORNL scientists who have uncovered remarkable genetic secrets that bring us closer to making poplar an economical and sustainable source of energy and materials.

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    HPCwire Editor's Choice Award (logo crop) for Best Use of HPC in the Life Sciences
    JGI Part of Berkeley Lab Team Awarded Best Use of HPC in Life Sciences
    The HPCwire Editors Choice Award for Best Use of HPC in Life Sciences went to the Berkeley Lab team comprised of JGI and ExaBiome Project team, supported by the DOE Exascale Computing Project for MetaHipMer, an end-to-end genome assembler that supports “an unprecedented assembly of environmental microbiomes.”

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    With a common set of "baseline metadata," JGI users can more easily access public data sets. (Steve Wilson)
    A User-Centered Approach to Accessing JGI Data
    Reflecting a structural shift in data access, the JGI Data Portal offers a way for users to more easily access public data sets through a common set of metadata.

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    Phytozome portal collage
    A More Intuitive Phytozome Interface
    Phytozome v13 now hosts upwards of 250 plant genomes and provides users with the genome browsers, gene pages, search, BLAST and BioMart data warehouse interfaces they have come to rely on, with a more intuitive interface.

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    screencap from Amundson and Wilkins subsurface microbiome video
    Digging into Microbial Ecosystems Deep Underground
    JGI users and microbiome researchers at Colorado State University have many questions about the microbial communities deep underground, including the role viral infection may play in other natural ecosystems.

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    Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical output due to growth and viability constraints. Cell extracts provide an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at volumetric productivities greater than the source strains. (Blake Rasor)
    Boosting Small Molecule Production in Super “Soup”
    Researchers supported through the Emerging Technologies Opportunity Program describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system.

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    These bright green spots are fluorescently labelled bacteria from soil collected from the surface of plant roots. For reference, the scale bar at bottom right is 10 micrometers long. (Rhona Stuart)
    A Powerful Technique to Study Microbes, Now Easier
    In JGI's Genome Insider podcast: LLNL biologist Jennifer Pett-Ridge collaborated with JGI scientists through the Emerging Technologies Opportunity Program to semi-automate experiments that measure microbial activity in soil.

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    A view of the mangroves from which the giant bacteria were sampled in Guadeloupe. (Hugo Bret)
    Giant Bacteria Found in Guadeloupe Mangroves Challenge Traditional Concepts
    Harnessing JGI and Berkeley Lab resources, researchers characterized a giant - 5,000 times bigger than most bacteria - filamentous bacterium discovered in the Caribbean mangroves.

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    In their approved proposal, Frederick Colwell of Oregon State University and colleagues are interested in the microbial communities that live on Alaska’s glacially dominated Copper River Delta. They’re looking at how the microbes in these high latitude wetlands, such as the Copper River Delta wetland pond shown here, cycle carbon. (Courtesy of Rick Colwell)
    Monitoring Inter-Organism Interactions Within Ecosystems
    Many of the proposals approved through JGI's annual Community Science Program call focus on harnessing genomics to developing sustainable resources for biofuels and bioproducts.

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    Coloring the water, the algae Phaeocystis blooms off the side of the sampling vessel, Polarstern, in the temperate region of the North Atlantic. (Katrin Schmidt)
    Climate Change Threatens Base of Polar Oceans’ Bountiful Food Webs
    As warm-adapted microbes edge polewards, they’d oust resident tiny algae. It's a trend that threatens to destabilize the delicate marine food web and change the oceans as we know them.

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May 23, 2018

Iron-rich Microbial Mats’ Main Players: Marsarchaeota

The iron (Fe)-oxide terraces at Echinus Geyser form from the oxidation of ferrous Fe, and the temperature across the terraces ranges from ~ 60-70ºC, while pH values vary from 3.4 to 3.6. A very thin (1-2 mm) layer of water flowing over the Fe-oxide terraces from the outflow channel at Echinus Geyser, located in Yellowstone National Park’s Norris Geyser Basin, is thought to provide the needed oxygen to create habitats suitable for the Marsarchaeota. (Bill Inskeep)Novel archaeal lineage found in Yellowstone may have been important in early Earth conditions. The Science Through a combination of sequencing tools and techniques applied to samples collected from acidic iron-oxide microbial mats in Yellowstone National Park over time, researchers have discovered and characterized a novel phylum-level lineage of archaea with at least two major… [Read More]

January 8, 2018

The fungus that made itself at home

Serpula lacrymans var shastensis decomposing a large Shasta red fir (Abies magnifica var shastenis) in its natural habitat in Mt Shasta, California. (Håvard Kauserud)Retracing how the dry rot Serpula lacrymans adapted to a new ecological habitat. The Science By comparing genetic information from similar organisms, researchers have gained insights on why the dry rot (Serpula lacrymans) is so destructive in houses. A study involving six brown rot fungi reveals the genomic changes Serpula lacrymans has undergone in adapting… [Read More]

December 13, 2017

An Addiction Crucial to a Fungus’ Reproduction

Sexual reproduction in Rhizopus microspores: (a) Successful mating between fungi harboring bacteria; (b) Lack of sex between mates cured of endobacteria. (Stephen Mondo)A fungus relies on bacteria to regulate key components of its reproductive machinery The Science To better understand how beneficial organisms (symbionts) are transmitted between host generations, researchers investigated the role that bacteria living within a host (endosymbionts) have on fungal host reproduction, and the reproductive genes they regulate. The bacterial endosymbiont, Burkholderia, is recognized… [Read More]

December 1, 2017

Succulent Genes for Water Use Efficiency

In Nature Communications, researchers sequenced and analyzed the genome of Kalanchoe fedtschenkoi (lavender scallops) to better understand how this plant transitioned from C3 to CAM photosynthesis. (Forest and Kim Starr, Flickr CC BY 2.0)Comparative genomics identifies sequences involved in photosynthesis under reduced water conditions.   The Science In the presence of sufficient water and light, most plants conduct photosynthesis through what is known as the C3 pathway. As plants spread out and adapted to live in a variety of environments, they developed alternate photosynthesis pathways, known as C4 and… [Read More]

November 24, 2017

Insights into carbon fixation in the dark ocean  

View of Saanich Inlet - one of the areas sampled for this study - from Malahat. (BC Ministry of Transportation, Flickr CC BY-NC-ND 2.0)Nitrite-oxidizing bacteria have bigger role in marine carbon cycle than previously thought The Science Researchers have identified the most abundant and globally distributed nitrite-oxidizing bacteria (NOB) in the oceans, through single-cell genomics and community meta-omics. They have also calculated the NOB’s contribution toward trapping carbon beneath the sunlit waters and determined that though these bacteria… [Read More]

October 4, 2017

A Technique for Targeted Improvement

A bioluminescent assay helped researchers visually quantify the colonization ability of P. simiae mutant strains identified by the RB-TnSeq screen. (Benjamin Cole)Establishing a genome-wide map of bacterial genes crucial for colonization of plants by beneficial microbes The Science Working with the plant growth-promoting bacterium Pseudomonas simiae, researchers have identified 115 genes that negatively affect its ability to colonize a plant root system when mutated. The Impact A plant’s health and development is influenced by the complex… [Read More]

September 5, 2017

Scaling Microbial Genomics Discoveries for Ecosystem Modeling

Study co-author Rhonzhong Ye and graduate student Jennifer Morris collecting greenhouse gas fluxes from the rice fields studied on Twitchell Island, CA. (Wyatt Hartman)Nutrient availability in model wetlands helps regulate microbial metabolism and soil carbon cycling rates The Science Studying microbial communities in San Joaquin Delta rice fields, researchers linked microbial metabolism and nutrient availability to soil carbon cycling rates. The Impact Establishing the inter-relationships among microbial metabolism, nutrient availability and soil carbon cycling rates is critical to… [Read More]

July 31, 2017

Tracking Microbial Succession in Petroleum Wells

Shell researchers collected samples from oil wells in a North Sea oil field like this one. (Credit: Berardo62 via Flickr CC BY-SA 2.0)Offshore subsurface reservoirs demonstrate human impacts on well microbiomes. The Science Microbes are invisible to the naked eye, but play key roles in maintaining the planet’s biogeochemical cycles. In the Earth’s subsurface, microbes have adapted to thrive in the relatively stable extreme conditions. To learn more about how some of these populations respond to disruptions… [Read More]

July 19, 2017

Insights into A Eukaryotic Alga

Porphyra umbilicalis (laver) attains high biomass despite the high levels of stress in its habitat in the upper intertidal zone of the North Atlantic, as shown here at low tide at Sand Beach, Acadia National Park, Maine. (Susan Brawley)The genome of Porphyra umbilicalis reveals the mechanisms by which it thrives in the intertidal zone The Science Through the Community Science Program of the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, a 50-member team led by University of Maine, Carnegie Institution for Science, and East… [Read More]

July 10, 2017

New Technology to Access Microbial Dark Matter

Integrated microfluidic circuit used to perform mini-metagenomic microbial cell partitioning and genomic DNA amplification. (Brian Yu)Demonstrating the microfluidic-based, mini-metagenomics approach on Yellowstone hot springs samples. The Science Stanford researchers extracted 29 novel microbial genomes from Yellowstone hot spring samples while still preserving single-cell resolution to enable accurate analysis of genome function and abundance. The work was enabled by the Emerging Technologies Opportunity Program (ETOP) of the U.S. Department of Energy… [Read More]
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