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… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … to facilitate the discovery of new bio-based molecules that can drive innovations in bioenergy, sustainable … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … on identifying and characterizing haloperoxidases from bacteria. And with Christian, I started getting a little bit … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

When submitting sequences to the JGI DNA Synthesis program, please include the following items: … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … large-scale genomic data to advance microbial research that drives sustainable solutions in energy, agriculture and … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from …

And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … general feasibility prior to submitting a BER proposal that includes a JGI request.  Proposals whose scope was not … biofuels, advancing the federal initiative that seeks to reduce U.S. gasoline consumption by 20% within 10 years …