Ben Bowen

Specializing in mass spectrometry-centered projects, Dr. Bowen’s work focuses on developing high-performance computing workflows and integrating mathematics and chemistry for advanced analysis, modeling, and data integration. Dr. Bowen’s expertise in spectral alignment, molecular networking, chemoinformatics, and bioinformatics facilitates impactful scientific discoveries, supporting the DOE’s Biological and Environmental Research user community in their bioenergy and environmental objectives.

Education

Awards and Honors

Selected Publications

Raad, M., Rond, T., Rübel, O., Keasling, J., Northen, T., & Bowen, B. (2017). OpenMSI Arrayed Analysis Toolkit: analyzing spatially defined samples using mass spectrometry imaging. Analytical chemistry, 89(11), 5818–5823.
Baran, R., Brodie, E., Mayberry-Lewis, J., Hummel, E., Da Rocha, U., Chakraborty, R., Bowen, B., Karaoz, U., Cadillo-Quiroz, H., Garcia-Pichel, F., & others (2015). Exometabolite niche partitioning among sympatric soil bacteria. Nature communications, 6(1), 8289.
Yao, Y., Sun, T., Wang, T., Ruebel, O., Northen, T., & Bowen, B. (2015). Analysis of metabolomics datasets with high-performance computing and metabolite atlases. Metabolites, 5(3), 431–442.
Yang, J., Rubel, O., Prabhat, Mahoney, M., & Bowen, B. (2015). Identifying important ions and positions in mass spectrometry imaging data using CUR matrix decompositions. Analytical chemistry, 87(9), 4658–4666.
Wang, Y., Kora, G., Bowen, B., & Pan, C. (2014). MIDAS: a database-searching algorithm for metabolite identification in metabolomics. Analytical chemistry, 86(19), 9496–9503.
Louie, K., Bowen, B., McAlhany, S., Huang, Y., Price, J., Mao, J.h., Hellerstein, M., & Northen, T. (2013). Mass spectrometry imaging for in situ kinetic histochemistry. Scientific reports, 3(1), 1656.
Rübel, O., Greiner, A., Cholia, S., Louie, K., Bethel, E., Northen, T., & Bowen, B. (2013). OpenMSI: a high-performance web-based platform for mass spectrometry imaging. Analytical chemistry, 85(21), 10354–10361.
Hwang, H., Bowen, B., Lefort, N., Flynn, C., De Filippis, E., Roberts, C., Smoke, C., Meyer, C., Højlund, K., Yi, Z., & others (2010). Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes, 59(1), 33–42.
Bowen, B., & Northen, T. (2010). Dealing with the unknown: metabolomics and metabolite atlases. Journal of the American Society for Mass Spectrometry, 21, 1471–1476.
Storm, P., Aits, S., Puthia, M., Urbano, A., Northen, T., Powers, S., Bowen, B., Chao, Y., Reindl, W., Lee, D., & others (2011). Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene, 30(48), 4765–4779.

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Metabolomics Technology

Computational Metabolomics Lead