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A mechanism for de novo intron insertion

Introns are the parts of a gene sequence that are not expressed in the protein. In the August 30 issue of Nature Communications, a team led by DOE JGI’s Eukaryote Program head Dan Rokhsar and Uffe Hellsten describe a potential mechanism by which introns have been added to a genome sequence since what they refer… [Read More]

Sponge genome project in New Scientist

Sponges are primitive creatures with a body plan unlike that of any other living organism. They are also our most distant animal cousins. Now that their genetic make-up has finally been sequenced, it could explain one of the greatest mysteries of evolution: how single-celled organisms in the primordial oceans evolved into complex multicellular animals with… [Read More]

Frog genome project on NIH Research Matters

A team of scientists led by the U.S. Department of Energy (DOE) Joint Genome Institute and the University of California, Berkeley, set out to add to the set of X. tropicalis research tools by sequencing its genome. The team, which included researchers from NIH’s National Library of Medicine (NLM) and National Cancer Institute (NCI), was… [Read More]

Frog genome project on BBC

“When human genome work was wrapping up around 2002, we were discussing what should be next,” JGI’s Uffe Hellsten told BBC News. “At that time there were a couple of furry mammals in the pipeline, and the chicken and at least two fish – but there seemed to be a gaping hole in the branch… [Read More]

Frog genome project on ScienceNews

A new study, published April 30 in Science, lays out the genetic blueprint of the Western clawed frog, Xenopus tropicalis. A larger cousin of X. tropicalis, called Xenopus laevis, is a popular laboratory organism for studying development. But with a genome about half the size of X. laevis’, the Western clawed frog has easier DNA… [Read More]

Frog genome project on QB3

When the Joint Genome Institute decided to sequence a frog genome, however, the Xenopus research community recommended X. tropicalis over X. laevis because tropicalis has half the genome size. While X. tropicalis is diploid, with two copies of each gene on 10 pairs of chromosomes, the X. laevis genome has undergone duplication and could have… [Read More]

Frog genome project on UPI

Sater said the frog is extremely important for studies of embryonic development and the regulation of cell division since its genes are highly similar to those in mice and humans. Other similarities include the frog’s molecular communication pathways that serve as lines of communication between cells and are critical for the maintenance and differentiation of… [Read More]

Frog genome project on 7th Space

“Sequencing and assembling a genome is basically science infrastructure – the equivalent of building roads and bridges – and once the infrastructure is in place, everyone can benefit,” Sater said. “This work is an enormous contribution to research now in progress throughout the world, and essentially every study that uses Xenopus as a research animal… [Read More]

Frog genome project on Medical News Today

The findings published in Science are based on the DNA of a single African clawed frog whose DNA was broken down into small pieces that were replicated many, many times, then sent to laboratories around the world for analysis. The project sprang from a meeting of researchers in Walnut Creek, Calif., in 2002, when the… [Read More]

Frog genome project on the Courier-Journal

The frog is cousin to the Western clawed frog (Xenopus laevis), which is often used to study embryo development and cell biology and having its genome will make sequencing laevis easier to do, said Harland.   Because frogs are especially sensitive to minute amounts of chemical that mimic hormones and can disrupt their endocrine system,… [Read More]