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Database provides details on river microbes in 90% of US continental watersheds. The … describe a dataset of microbial genomes sampled from rivers covering 90% of the watersheds in the continental … They noted this may be the first publicly available, river-focused microbial resource that provides information …

… of a microorganism. So around 1985, I said, why aren’t we studying microbes in the ocean? Why don’t we do that? DAN … Everything that’s in there is rinsed into the ocean through rivers and rainwater and spores flying into the ocean. So, … 2,000, 5,000 different cells, different colors, different sizes, different shapes, motility, all this stuff. But when …

… to Roger Linington, from Simon Fraser University in British Columbia, Canada. This is the last of the podcasts we … natural products science as a field, we have arguably been studying microbial natural products in an ordered way for … cluster. So either both of those pools have to increase in size dramatically, or there has to be a significant …

ALISON TAKEMURA: So Nadine, what got you interested in studying natural products? NADINE ZIEMERT: Like almost … really then helps you to get back to, oh, why am I actually studying that question? DAN UDWARY: We know each other I … she was leading this team effort to sequence microbiomes of rivers around the world and that JGI was being very helpful …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated …

… in defense, nutrient acquisition and communication. Studying how these compounds are biosynthesized and their roles in the environment, can unlock new … This is based on extensive computational analyses of BGC size and complexity, BGC sequence composition, metabolic …

Collins have a massive undertaking: sequencing the world’s river microbiomes. And they’re using team science to do it.   …

… to assess microbial activity across ecosystems.  By studying microbial communities and their interactions, the …

… them that it looked to be of a certain number of modules in size, they then quickly were able to then solve the … Alison: What’s a favorite fun story you have about studying these different kinds of organisms, or one …

… just now switching from intermicrobial interactions, studying intermicrobial interactions by imaging interactions … 20 analogs at this point. And Casey and Nikolaou synthesized the everninomicin at Scripps, I guess, 22 years ago. … looked at the grant applications for the last 40 years for studying biosynthetic pathways, all of them said that a …

And these were not in natural products, these were in studying regulatory mechanisms of, first, E. coli and then … build out much more of an integrative genomics approach to studying environments, studying organisms, to looking at … example.  DAN: Right. So then secondary metabolism is a driver for our technology?  NIGEL MOUNCEY: Oh, yeah, I think …