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… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … and archaeal lineages to improve phylogenetic analysis, metagenomic annotations, and function distribution. These are … capability of microbial communities based on their metagenome sequence, in the context of reference isolate …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …

… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … not essential for fundamental growth, provide critical advantages to the organisms producing them, and are often … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … genomes are critical to serve as phylogenetic anchors for metagenomes studies.  While uncovering the metabolic potential … virus diversity and host interactions through global metagenomics.” Nature 578(7795): 432-436 (2020). Seshadri R., …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … bound to it and maybe there will be some a affinity tag or a fluorescent tag, and so you can use that as a readout of activity. And I …

… into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … we want to talk a little bit about. It’s sort of early stages. But I think that is emblematic of some of the … don’t we do that? DAN UDWARY: What were you doing before bacteria then? BILL FENICAL: Well, we were studying marine …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … products and got really interested in thinking about how bacteria actually are able to make some of these really … allow that to bind. Your receptor also typically has some tag so that you can then pull down the receptor with that …

The Metagenome Program uses advanced sequencing technologies to … in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their … and characterizing microbial diversity, work in the Metagenome Program uses several experimental approaches to …

… about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … That is one of the really big frontiers for the next stage of natural product drug discovery I think. Or even … computational skills among biologists JGI CSP Proposal: Metagenomic mining of natural product diversity and …

And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  … ended up doing was pursuing with Jacques Ravel, at TIGR, metagenome sequencing, which was very early days for that …

… they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot of … of secondary metabolite pathways as viewed through metagenome studies, and what more JGI and others can do to …