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… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … and I hope you’ll enjoy it too. So here we go– episode 13 with Paco Barona-Goméz. DAN UDWARY: Hey Alison. ALISON … that particular pathway. So all these BGCs encode between 80-90% of all known genes. Or genes that you can put a name …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … learn as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … to degrade, using something like a specific lactonase and modify behaviors to try to change functions in some …

… So we might not be interested in, say, the drug discovery mode of genome mining. But I do do a lot of genome mining … Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might be a … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… conclusions .”  Nature Communications Volume 15 Article 9873. Buscaglia, M. et all (2024) “ Adaptation strategies of … marine ecosystems .”  The ISME Journal , Volume 18 Issue 1. Pitot, T.M., et al (2024) “ Conservative taxonomy …

… Brad: Yeah, for sure. So we’re going back to the mid-late ’80s. And at that time, you know, it’s before genomics … sequence area encoded a polyketide synthase, with many modules of high identity, and the question was were there … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

… in this hypersaline environment, which can range from 8% to 28% salinity. We have toxic metals, so these … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … done on JGI’s new supercomputer called Dori. I think it’s a moderately sized machine. It’s not super huge, but it’s …

… But the structure of which was not known until the middle ’80s. And then the first time we saw the structure that Dan … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … is a geographic distribution. So they were collected from 108 countries and regions. So, this is really collected from …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … as the fermentation process itself. And we built a nice modeling feedback loop for the fermentation work, which … NIGEL MOUNCEY: Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary …

… medicines and medicinal plants with the pursuit of modern drug discovery. It’s also the kind of book we can … medicine. I’m also a mom of four kids now so ranging from 8 to 17 in age, so my home life is very busy. And I’m also a … plants and bringing them back is not your jam, the good news is there’s this amazing resource that can be provided …