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… research and to help them translate genomic information into biological function.  The emphasis is on projects … JGI’s DNA synthesis and ‘omics capabilities to enhance understanding of gene and genome function, particularly … form and are reviewed annually. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… but-- [LAUGHS] I feel like a lot of people hedge their way into natural products by starting out in synthesis and then … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … to take a little bit of time. So we are starting with doing DAP-seq and we're hoping I think to get the DAP-seq done in …

… JGI innovates protocol revealing how genetic variations in sequences affect traits. In a text file, the rows of letters … on is known as DNA affinity purification sequencing or DAP-seq. The technology was developed by Ronan O’Malley , … genomes of different species. This can provide insights into how they orchestrate sets of genes to execute similar …

… I wanted to start, maybe just by asking you how did you get into the field of natural products?   NANCY: Yeah, that’s a … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   …

… systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … development of high performance plants and microbes, and understanding microbiome interactions. The  insights derived …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … We then investigate the coding potential to find novel functions that may impact microbiome structure and … viruses and cellular life, providing unique insights into viral evolution and complexity, and encode for a …

… and bioenergy crop enhancement. The program aims to tap into the largely unexplored biochemical diversity within … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The …

… – problems that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, … Secondary Metabolites Science Program, which I was hired into, and my job is to do cool research, and also to talk to … in a cell or a living creature that make it specialized or adapted to its environment. Chemical- chemistry-wise. So it’s …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in … govern ecosystem processes. This research provides insights into microbial diversity and metabolic potential, with … sustainability, and many other applications. By understanding how microbes contribute to ecosystem …

… question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked … before– or kind of around about when the first genome sequencing was done. But natural products– marine natural … Dan Udwary: Yeah. Kate Duncan: So they’re also incredibly adaptable. I think there has been some examples of real …

… and you can still make more of it, then you start going into human trials or animal trials first, and going through … and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … in terms of – well it’s really simple in terms of understanding it because it’s an assembly line. You just go …

… work we’ve determined that the ANMG deposits those bacteria into the jelly coat of the eggs. And so these eggs are laid … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … Have been in the last several years figuring out how to adapt what we want to get out of the mass spectrometer to …