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… research and to help them translate genomic information into biological function.  The emphasis is on projects … JGI’s DNA synthesis and ‘omics capabilities to enhance understanding of gene and genome function, particularly … form and are reviewed annually. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … to take a little bit of time. So we are starting with doing DAP-seq and we're hoping I think to get the DAP-seq done in … to Medicines outreach program JGI Release on DAP-Seq: Enlarging Windows into Understanding Gene Functions Purdue's …

JGI innovates protocol revealing how genetic variations in sequences affect traits. In a text file, the rows of letters … on is known as DNA affinity purification sequencing or DAP-seq. The technology was developed by Ronan O’Malley , … genomes of different species. This can provide insights into how they orchestrate sets of genes to execute similar …

… systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … metabolomics with genomic data to gain insights into how small molecules function within plants, microbes, …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in … govern ecosystem processes. This research provides insights into microbial diversity and metabolic potential, with … sustainability, and many other applications. By understanding how microbes contribute to ecosystem …

… work we’ve determined that the ANMG deposits those bacteria into the jelly coat of the eggs. And so these eggs are laid … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … Have been in the last several years figuring out how to adapt what we want to get out of the mass spectrometer to …

I wanted to start, maybe just by asking you how did you get into the field of natural products?   NANCY: Yeah, that’s a … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   …

And with Christian, I started getting a little bit more into fungi and learning the differences of all the genetic … have no problem living there. So we’re looking at how they adapt to these extreme environments. And then can we use … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore … linking strain-level genetic variation to ecological niche adaptations.  Single cell sequencing approaches are also used … interactions: In an effort to gain insights into the interactions between microbial organisms and how …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … detoxifying soils, interacting with other organisms, and adapting to environmental changes. The program lays the … into chemical energy — and its implications for carbon sequestration, renewable energy and agricultural …

… started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology to help … he has an accent, and, so, I don’t really have any trouble understanding him, but I know from the download stats that … for every episode we put out. I actually put a lot of time into preparing those transcripts, so I hope somebody’s going …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … it will be really good to maybe start with how did you get into this field? How did you get into natural products? …