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… is a “fireside chat”-style podcast about natural products and the science and scientists of secondary metabolism. Natural products, secondary metabolites, and specialized metabolites all …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential … Science 2018, Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). … Harrington LB, et al (2018) Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science …

… With a new methodology, scientists are now getting more complete genomic results … earth, but most species do not grow easily in the lab. To access the genomes of uncultured  microbes , scientists … Primary Template-Directed Amplification (PTA) yields a much higher completion, above 80% in most cases. The Impact …

… The Integrative Genomics Building (IGB) seen above is home to the DOE Joint … an increased number of users with a record output of products, making data easier to access and use, and by investing in the latest advanced … develop new materials, and manufacture the products and fuels we need. The organisms on our planet encode …

… controls when and where lights turn on or machines start humming, gene regulation determines when and where … as  Arabidopsis and sorghum. Together, these datasets allow scientists to explore how gene regulation varies across cell … at an unprecedented scale.  “All of the data are publicly accessible,” Baumgart stressed. “We want people to use it, …

… a changing planet. Mo Kaze is a University of California (UC), Merced graduate student working with  Susannah Tringe , … Kaze was part of the  2018 cohort of the JGI-UC Merced Genomics Internship Program, and is part of  Mark Sistrom’s … Berkeley National Laboratory, is committed to advancing genomics in support of DOE missions related to clean energy …

… The JGI mural on the 3rd floor of the Integrative Genomics Building whimsically references dozens of iconic … to advancing the frontiers of environmental and energy genomics. Click on the images below to learn about the …