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2024 Progress Report
The Integrative Genomics Building (IGB) seen above is home to the DOE … for a sustainable bioeconomy. Mission  As a U.S. Department of Energy Office of Science user facility, we provide … 39,870 projects in FY24 We generated 871 Terabases of sequence We synthesized 9.7 Megabases of DNA We processed …
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Applying Viral Genomics Expertise to Understanding the Human Virome
JGI researchers lend expertise to develop tools and data hub for NIH … viruses outnumber the microbes by at least another order of magnitude. For years, scientists at the DOE Joint Genome … collection of UViGs by identifying contiguous viral sequences (“contigs”) from thousands of ecologically diverse …
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Ancient Algae Reveal Secrets of Plant Evolution
Research uncovers the genetic foundations that helped plants … 600 million years ago. The Science By studying the genes of land plants’ closest algal relative,  Zygnematophyceae , … Berkeley National Laboratory (Berkeley Lab), scientists sequenced the genomes of four  Zygnematophyceae algae, which …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
A group led by JGI scientists have made strides in improving … ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 kb) in a single step, directly into the … domesticate some 60 strains, inserting into them a genetic sequence that acts as a “landing pad.” Mouncey adds, “Once …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
With a new methodology, scientists are now getting more complete … from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for understanding the … Amplification to generate enough DNA to put on a sequencer. As previously mentioned, it’s a method that’s …
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Methane Makers in Yosemite’s Lakes
Meet researchers who have hiked, rafted and met local wildlife (a marmot!) as … the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains. These lakes are isolated, …
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Tracking the Origins of Methane-Producing Microbes
Mini-Metagenomics Approach Helps Identify Novel Archaeal Methane … archaea are estimated to produce 500 million tons of methane a year, which is over half the total global … the microbes into small pools of cells that were then sequenced separately. From these samples, 111 …
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From Berkeley to Binghamton: Tracking Strawberry Evolution
In the summer of 2015, Adam Session was a postdoc working at the DOE Joint … and the  oilseed crop false flax – genomes that have been sequenced by the JGI – and the common strawberry, which is …
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Inspiring STEM Careers Through a Hands-on Everglades Microbiome Study
Journal publication caps JGI pilot project with fledgling Florida high … school scientists. The Florida Everglades evokes images of fanboats skimming over swamps, while alligators peer through the waters and clouds of insects hover just above. Described as a “river of grass” …
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iPHoP: A Matchmaker for Phages and their Hosts
…   To understand virus-host dynamics, computation helps fill in what … With metagenomic sequencing, researchers have found more of these viruses than ever before, in all kinds of ecosystems. However, matching these viral genetic sequences to their hosts is crucial to understanding what …
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Engagement Webinar: What Can You Do With An Approved CSP Functional Genomics Call Proposal?
On July 8, JGI’s DNA Synthesis Science group held a  JGI Engagement: Accessing … really fully exist back then,” said Hal Alper, a University of Texas at Austin professor, “but we really first heard … the researchers will receive a FedEx package with the sequenced, quality controlled population representing the …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
A special issue of Synthetic Biology celebrates research enabled by … and synthesis work. This is where the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office …
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