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Doubling Down on Known Protein Families
Using a novel computational approach, researchers confirm microbial diversity is wilder than ever. Imagine … researchers exploring a dark room with a flashlight, only able to clearly identify what falls within that single …
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Toward More Reproducible, Reusable Stable Isotope Probing Experiments
As SIP experiments shed more light on microbial communities than ever before — especially with … genome-resolved metagenomes and will be implementing new tools in KBase to tackle the bioinformatic challenges … with the corresponding data analysis. … MetaSIPSim Toolkit Simulating metagenomic stable isotope probing …
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Extracting the Secrets of Secondary Metabolites
… biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not essential for growth … Interspaced Short Palindromic Repeats) is the leading tool for accurately editing genomes, its effectiveness has historically been limited due to the lack of robust tools available for carrying CRISPR into microorganisms. …
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JGI on the 2020 Highly Cited Researchers List
Congratulations to the 2020 Highly Cited Researchers at the … are part of a team that  developed CheckV , an automated tool to help researchers assess and improve the quality of … team that  released a reference genome sequence and genomic toolkit for the perennial grass  Miscanthus sinensis in  …
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JGI Contributes Eight to 2023 Highly Cited Researchers list
Congratulations to the 2023 Highly Cited Researchers from the JGI … in their chosen field or fields through the publication of multiple highly cited papers during the last decade” … also worked together on the development of a new software tool called geNomad that identifies and classifies mobile …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… enabled by the JGI DNA Synthesis Science Program. Fashioning DNA outside a cell is key to interrogating what genes … developed thousands of DNA constructs encoding a molecular tool to repress targeted genes in the organism. The team demonstrated that this tool, called CRISPR inhibition or CRISPRi, works (see the …
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Genomic variation within the maize stiff‐stalk heterotic germplasm pool
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JGI User Executive Committee Expands
… of Science User Facility located at Lawrence Berkeley National Laboratory (Berkeley Lab). They are: Ivan Baxter of the … more plant proposals and provide feedback on pangenome tool development. Maurice is a fungal evolutionary ecologist … also interested in developing or improving bioinformatics tools that can help with dataset analysis, as well as how …
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Fishing for Novel Cellulose Degraders
… single-cell genomic approach to bioprospecting. The Science One of the most vital pieces of equipment for fly fishing is … of Science User Facility located at Lawrence Berkeley National Laboratory (Berkeley Lab). Using a single-cell screen, … cellulose-degrading microbes. The new technique is another tool for microbial ecologists to learn more about the …
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Boosting Small Molecule Production in Super “Soup”
… from engineered yeasts still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: … smoothly. As reported August 26, 2021, in Nature Communications , researchers led by Hal Alper at The University of … Michael Jewett of Northwestern University describe a two-pronged approach that starts with engineered yeast cells but …
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A Plant Root Atlas for Tracking Developmental Trajectories
… zu Berlin   has developed an atlas that maps gene expression patterns in the  Arabidopsis root, profiling nearly 100,000 single root cells and combining the information with previously published datasets. The work was  … Relevant Links: Single-Cell Data Viewer Tool on Phytozome Biosciences News:  Plant Single-Cell …
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For the Tiniest Archaea, A Genomic Switch of Friend or Foe
… hitchhikers. These organisms are abundant and yet exceptionally small, with mini genomes to match. As a result, they … to survive. To fill in their nutrient gaps, they must latch onto a larger host — often, a fellow archaeal microbe. … One of these systems, the CRISPR-Cas9 system, is a powerful tool in gene editing, but many other systems exist. …
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