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JGI Contributes Eight to 2023 Highly Cited Researchers list
Congratulations to the 2023 Highly Cited Researchers from the JGI … in their chosen field or fields through the publication of multiple highly cited papers during the last decade” … also worked together on the development of a new software tool called geNomad that identifies and classifies mobile …
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Extracting the Secrets of Secondary Metabolites
… biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not essential for growth … Interspaced Short Palindromic Repeats) is the leading tool for accurately editing genomes, its effectiveness has historically been limited due to the lack of robust tools available for carrying CRISPR into microorganisms. …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… enabled by the JGI DNA Synthesis Science Program. Fashioning DNA outside a cell is key to interrogating what genes … developed thousands of DNA constructs encoding a molecular tool to repress targeted genes in the organism. The team demonstrated that this tool, called CRISPR inhibition or CRISPRi, works (see the …
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Genomic variation within the maize stiff‐stalk heterotic germplasm pool
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JGI User Executive Committee Expands
… of Science User Facility located at Lawrence Berkeley National Laboratory (Berkeley Lab). They are: Ivan Baxter of the … more plant proposals and provide feedback on pangenome tool development. Maurice is a fungal evolutionary ecologist … also interested in developing or improving bioinformatics tools that can help with dataset analysis, as well as how …
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Fishing for Novel Cellulose Degraders
… single-cell genomic approach to bioprospecting. The Science One of the most vital pieces of equipment for fly fishing is … of Science User Facility located at Lawrence Berkeley National Laboratory (Berkeley Lab). Using a single-cell screen, … cellulose-degrading microbes. The new technique is another tool for microbial ecologists to learn more about the …
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Boosting Small Molecule Production in Super “Soup”
… from engineered yeasts still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: … smoothly. As reported August 26, 2021, in Nature Communications , researchers led by Hal Alper at The University of … Michael Jewett of Northwestern University describe a two-pronged approach that starts with engineered yeast cells but …
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A Plant Root Atlas for Tracking Developmental Trajectories
… zu Berlin   has developed an atlas that maps gene expression patterns in the  Arabidopsis root, profiling nearly 100,000 single root cells and combining the information with previously published datasets. The work was  … Relevant Links: Single-Cell Data Viewer Tool on Phytozome Biosciences News:  Plant Single-Cell …
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For the Tiniest Archaea, A Genomic Switch of Friend or Foe
… hitchhikers. These organisms are abundant and yet exceptionally small, with mini genomes to match. As a result, they … to survive. To fill in their nutrient gaps, they must latch onto a larger host — often, a fellow archaeal microbe. … One of these systems, the CRISPR-Cas9 system, is a powerful tool in gene editing, but many other systems exist. …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
DNA for genome sequencing was no easy task. The traditional way of collecting them is through a method called Multiple Displacement Amplification, and most genomes that were acquired through it were … and researchers achieve their analysis goals. Offering this tool establishes the JGI as a leader in single-cell genomic …
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JGI@25: Fueling Investigation into Methane-Making Microbes
In honor of the JGI's 25th anniversary in 2022, we have … number of notable achievements that showcase our collaborations and capabilities to enable great science that will help … editing in RNA, rather than DNA alone. “It has become a tool widely used,” Leahy told JGI recently when we caught up …
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Taking Stock of the Known and Unknown Microbial Space
… of Science User Facility located at Lawrence Berkeley National Laboratory Berkeley Lab), have taken stock of the … the past three decades, their study assesses what fraction of the microbial diversity we know about, and proposes a … computationally derived MAGs have been a revolutionary tool for microbiology, it's a call to balance,” added …
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