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… there. This is Dan again, and you’re about to listen to the 3rd and final part of Natural Prodcast’s “Primer” episodes. … I hope you’ll stick around. But, for now, here’s episode 3 of the Primer! — DAN: So, you know, in the in the 50s 60s 70s, most of the exploration of this is done by …

… because I was always swimming or surfing. And you know, 25 hours a day we’re at the beach practically. It was just – … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student … with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

… they had the same conserved polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: … just did a low-resolution shotgun pass where we sequenced 500 runs. And then we used those to find gene clusters in … anybody in natural product discovery in any field and even 30 years ago would say it’s the [key to] success. And that …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … or it could be a whole grad student thesis to synthesize a 13C-labeled version of your compound. So people have been …

… that were acquired through it were usually only around 30% complete.  Described in  ISME Communications , a method … at least 80% complete when studied with PTA, compared to <30% complete when studied with MDA. With the introduction of … of Energy Joint Genome Institute (https:// ror.org/04xm1d337), a DOE Office of Science User Facility, is supported by …